Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors

Abstract Palm oil is enriched in vitamin E in the form of α-, γ-, and δ-tocotrienols. Dietary tocotrienol supplements have been shown to prevent atherosclerosis development in patients and preclinical animal models. However, the mechanistic basis for this health beneficial effect is not well establi...

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 2010-07, Vol.211 (1), p.278-282
Main Authors: Li, Fengjuan, Tan, Wenjuan, Kang, Zhanfang, Wong, Chi-Wai
Format: Article
Language:English
Subjects:
Animals
Apolipoproteins E - deficiency
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - prevention & control
Atherosclerosis prevention
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular
Chromans - pharmacology
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Liver X Receptors
Male
Medical sciences
Mice
Orphan Nuclear Receptors - metabolism
Palm Oil
Peroxisome Proliferator-Activated Receptors - drug effects
Peroxisome Proliferator-Activated Receptors - pharmacology
Peroxisome Proliferator-Activated Receptors - physiology
Plant Oils - pharmacology
PPAR agonist(s)
PPAR alpha - metabolism
Tocotrienols
Tumor Cells, Cultured
Vertebrates: cardiovascular system
Vitamin E
Vitamin E - analogs & derivatives
Vitamin E - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Palm oil is enriched in vitamin E in the form of α-, γ-, and δ-tocotrienols. Dietary tocotrienol supplements have been shown to prevent atherosclerosis development in patients and preclinical animal models. However, the mechanistic basis for this health beneficial effect is not well established. Peroxisome proliferator-activated receptors α, γ, and δ (PPARα, PPARγ, and PPARδ) are ligand regulated transcription factors that play essential preventive roles in the development of atherosclerosis through regulating energy metabolism and inflammation. In this study, we presented data that the tocotrienol rich fraction (TRF) of palm oil activated PPARα, PPARγ, and PPARδ in reporter based assays. Importantly, TRF attenuated the development of atherosclerosis in ApoE−/− mice through inducing PPAR target gene liver X receptor alpha (LXRα) and its down-stream target genes apolipoproteins and cholesterol transporters, suggesting that modulating the activities of PPARs is a key aspect of the in vivo action of tocotrienols.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2010.01.015