Comparison of turbo-PUVA and conventional American-style PUVA in the treatment of psoriatic patients

Background: Ultraviolet (UV)A protective properties of dihydroxyacetone (DHA) have been used as a topical UV‐resisting barrier to optimize psoralens and UVA (turbo‐PUVA). Starting doses and increments were based on the DHA diffuse reflectance spectroscopy‐derived protection factor. Objective: To eva...

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Published in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2010-08, Vol.26 (4), p.205-210
Main Authors: Moneib, Hoda Ahmed M., Salem, Samar Aballah Mohamed, Younis, Rehab Mohamed Mounir
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Dermatology
dihydroxyacetone
Female
Humans
Male
Medical sciences
Middle Aged
Photosensitizing Agents - therapeutic use
psoriasis
Psoriasis - drug therapy
Psoriasis. Parapsoriasis. Lichen
PUVA Therapy - methods
treatment
turbo-PUVA
Young Adult
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creator Moneib, Hoda Ahmed M.
Salem, Samar Aballah Mohamed
Younis, Rehab Mohamed Mounir
description Background: Ultraviolet (UV)A protective properties of dihydroxyacetone (DHA) have been used as a topical UV‐resisting barrier to optimize psoralens and UVA (turbo‐PUVA). Starting doses and increments were based on the DHA diffuse reflectance spectroscopy‐derived protection factor. Objective: To evaluate the efficacy of turbo‐PUVA in psoriatic patients using a simpler method for determining starting doses and increments, in comparison to the conventional American‐style PUVA photochemotherapy. Methods: Thirty psoriasis patients (15 on American‐style PUVA and 15 on turbo‐PUVA) were evaluated, each receiving PUVA twice weekly. Starting UVA dose was determined according to skin phototype for the American‐style PUVA group and according to the patient's skin phototype × DHA SPF 3 in turbo‐PUVA group. UVA increments used were 0.5–1.5 J/cm2 per treatment in American‐style PUVA and 25% of the previous dose in turbo‐PUVA. Results: Turbo‐PUVA group showed a significantly lower mean cumulative dose, a significantly higher psoriasis area and severity index score reduction, lesser mean number of treatment sessions, and less duration of treatment till remission (188.44±106.2 J/cm2, 92.164±1.975%, 11.2±3.52 session, and 1.4±0.44 months, respectively) than conventional American‐style PUVA group (255.13±18.304 J/cm2, 74.725±10.976%, 30±0.00 sessions, and 3.75±0.00 months, respectively). Conclusion: Turbo‐PUVA is more effective and time convenient for the treatment of psoriasis with less cumulative dose than the conventional American‐style PUVA.
doi_str_mv 10.1111/j.1600-0781.2010.00523.x
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Starting doses and increments were based on the DHA diffuse reflectance spectroscopy‐derived protection factor. Objective: To evaluate the efficacy of turbo‐PUVA in psoriatic patients using a simpler method for determining starting doses and increments, in comparison to the conventional American‐style PUVA photochemotherapy. Methods: Thirty psoriasis patients (15 on American‐style PUVA and 15 on turbo‐PUVA) were evaluated, each receiving PUVA twice weekly. Starting UVA dose was determined according to skin phototype for the American‐style PUVA group and according to the patient's skin phototype × DHA SPF 3 in turbo‐PUVA group. UVA increments used were 0.5–1.5 J/cm2 per treatment in American‐style PUVA and 25% of the previous dose in turbo‐PUVA. Results: Turbo‐PUVA group showed a significantly lower mean cumulative dose, a significantly higher psoriasis area and severity index score reduction, lesser mean number of treatment sessions, and less duration of treatment till remission (188.44±106.2 J/cm2, 92.164±1.975%, 11.2±3.52 session, and 1.4±0.44 months, respectively) than conventional American‐style PUVA group (255.13±18.304 J/cm2, 74.725±10.976%, 30±0.00 sessions, and 3.75±0.00 months, respectively). Conclusion: Turbo‐PUVA is more effective and time convenient for the treatment of psoriasis with less cumulative dose than the conventional American‐style PUVA.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/j.1600-0781.2010.00523.x</identifier><identifier>PMID: 20626823</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Dermatology ; dihydroxyacetone ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Photosensitizing Agents - therapeutic use ; psoriasis ; Psoriasis - drug therapy ; Psoriasis. Parapsoriasis. 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Starting doses and increments were based on the DHA diffuse reflectance spectroscopy‐derived protection factor. Objective: To evaluate the efficacy of turbo‐PUVA in psoriatic patients using a simpler method for determining starting doses and increments, in comparison to the conventional American‐style PUVA photochemotherapy. Methods: Thirty psoriasis patients (15 on American‐style PUVA and 15 on turbo‐PUVA) were evaluated, each receiving PUVA twice weekly. Starting UVA dose was determined according to skin phototype for the American‐style PUVA group and according to the patient's skin phototype × DHA SPF 3 in turbo‐PUVA group. UVA increments used were 0.5–1.5 J/cm2 per treatment in American‐style PUVA and 25% of the previous dose in turbo‐PUVA. Results: Turbo‐PUVA group showed a significantly lower mean cumulative dose, a significantly higher psoriasis area and severity index score reduction, lesser mean number of treatment sessions, and less duration of treatment till remission (188.44±106.2 J/cm2, 92.164±1.975%, 11.2±3.52 session, and 1.4±0.44 months, respectively) than conventional American‐style PUVA group (255.13±18.304 J/cm2, 74.725±10.976%, 30±0.00 sessions, and 3.75±0.00 months, respectively). Conclusion: Turbo‐PUVA is more effective and time convenient for the treatment of psoriasis with less cumulative dose than the conventional American‐style PUVA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>dihydroxyacetone</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>psoriasis</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>PUVA Therapy - methods</subject><subject>treatment</subject><subject>turbo-PUVA</subject><subject>Young Adult</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpFkcGO0zAQhi0EYruFV0C-IE4p4ziOnQOHqoLtwgoqtLscLddxhUtiZ20X2rfHaUuZw4w0880_sn-EMIEZyfF-OyM1QAFckFkJuQvASjrbP0OTy-A5mkADrKiooFfoOsYtAFQVkJfoqoS6rEVJJ6hd-H5QwUbvsN_gtAtrX6weHudYuRZr734bl6x3qsPz3gSrlStiOnQGHyHrcPppcApGpT6To8YQfbAqWY2HnHMzvkIvNqqL5vW5TtHDp4_3i2Vx9-3mdjG_KzQVnBa8aqqmFi1nROlNK3JhojZgCGNVXbampFS0DRVaCEKUAV0pIAJMtWZVfhGdoncn3SH4p52JSfY2atN1yhm_i5JT2vCGNpDJN2dyt-5NK4dgexUO8t_HZODtGVBRq24TlNM2_ucokKPWFH04cX9sZw6XOQE5GiW3cvRDjn7I0Sh5NEru5Wq5WrHjneK0b2My-8u-Cr9kzSln8sfXG0m_P95__sKXEuhfRNaT4Q</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Moneib, Hoda Ahmed M.</creator><creator>Salem, Samar Aballah Mohamed</creator><creator>Younis, Rehab Mohamed Mounir</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Comparison of turbo-PUVA and conventional American-style PUVA in the treatment of psoriatic patients</title><author>Moneib, Hoda Ahmed M. ; Salem, Samar Aballah Mohamed ; Younis, Rehab Mohamed Mounir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3873-7494968d751acfd851a586e0e155462de2338d938c8811ae0c4a0180e4b540623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>dihydroxyacetone</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>psoriasis</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>PUVA Therapy - methods</topic><topic>treatment</topic><topic>turbo-PUVA</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moneib, Hoda Ahmed M.</creatorcontrib><creatorcontrib>Salem, Samar Aballah Mohamed</creatorcontrib><creatorcontrib>Younis, Rehab Mohamed Mounir</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moneib, Hoda Ahmed M.</au><au>Salem, Samar Aballah Mohamed</au><au>Younis, Rehab Mohamed Mounir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of turbo-PUVA and conventional American-style PUVA in the treatment of psoriatic patients</atitle><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2010-08</date><risdate>2010</risdate><volume>26</volume><issue>4</issue><spage>205</spage><epage>210</epage><pages>205-210</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>Background: Ultraviolet (UV)A protective properties of dihydroxyacetone (DHA) have been used as a topical UV‐resisting barrier to optimize psoralens and UVA (turbo‐PUVA). Starting doses and increments were based on the DHA diffuse reflectance spectroscopy‐derived protection factor. Objective: To evaluate the efficacy of turbo‐PUVA in psoriatic patients using a simpler method for determining starting doses and increments, in comparison to the conventional American‐style PUVA photochemotherapy. Methods: Thirty psoriasis patients (15 on American‐style PUVA and 15 on turbo‐PUVA) were evaluated, each receiving PUVA twice weekly. Starting UVA dose was determined according to skin phototype for the American‐style PUVA group and according to the patient's skin phototype × DHA SPF 3 in turbo‐PUVA group. UVA increments used were 0.5–1.5 J/cm2 per treatment in American‐style PUVA and 25% of the previous dose in turbo‐PUVA. Results: Turbo‐PUVA group showed a significantly lower mean cumulative dose, a significantly higher psoriasis area and severity index score reduction, lesser mean number of treatment sessions, and less duration of treatment till remission (188.44±106.2 J/cm2, 92.164±1.975%, 11.2±3.52 session, and 1.4±0.44 months, respectively) than conventional American‐style PUVA group (255.13±18.304 J/cm2, 74.725±10.976%, 30±0.00 sessions, and 3.75±0.00 months, respectively). Conclusion: Turbo‐PUVA is more effective and time convenient for the treatment of psoriasis with less cumulative dose than the conventional American‐style PUVA.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20626823</pmid><doi>10.1111/j.1600-0781.2010.00523.x</doi><tpages>6</tpages></addata></record>
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subjects Adolescent
Adult
Aged
Biological and medical sciences
Dermatology
dihydroxyacetone
Female
Humans
Male
Medical sciences
Middle Aged
Photosensitizing Agents - therapeutic use
psoriasis
Psoriasis - drug therapy
Psoriasis. Parapsoriasis. Lichen
PUVA Therapy - methods
treatment
turbo-PUVA
Young Adult
title Comparison of turbo-PUVA and conventional American-style PUVA in the treatment of psoriatic patients
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