Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury

Abstract Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated proximal renal tubular epithelial cells in damaged regions. It may participate in the progress of renal injury or repair. Many studies have illustrated the different functions of...

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Bibliographic Details
Published in:Transplantation reviews (Philadelphia, Pa.) Pa.), 2010-07, Vol.24 (3), p.143-146
Main Authors: Huo, Wenqian, Zhang, Keqin, Nie, Zhilin, Li, Qiansheng, Jin, Fengshuo
Format: Article
Language:English
Subjects:
Animals
Biomarkers - analysis
Hepatitis A Virus Cellular Receptor 1
Humans
Kidney Diseases - diagnosis
Kidney Diseases - physiopathology
Membrane Glycoproteins - analysis
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - physiology
Receptors, Virus - analysis
Receptors, Virus - chemistry
Receptors, Virus - physiology
Surgery
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Summary:Abstract Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated proximal renal tubular epithelial cells in damaged regions. It may participate in the progress of renal injury or repair. Many studies have illustrated the different functions of KIM-1 in various renal diseases including protective functions in acute kidney injury and damaging functions in chronic kidney disease. Although, the exact functions of KIM-1 still remain unclear, some scientists speculate that KIM-1 is expected to be a therapeutic target for kidney injury. In this review, some of the known features and functions of KIM-1 are highlighted.
ISSN:0955-470X
1557-9816
DOI:10.1016/j.trre.2010.02.002