Effect of Modest Salt Reduction on Skin Capillary Rarefaction in White, Black, and Asian Individuals With Mild Hypertension

Microvascular rarefaction occurs in hypertension. We carried out a 12-week randomized double-blind crossover trial to determine the effect of a modest reduction in salt intake on capillary rarefaction in 71 whites, 69 blacks, and 29 Asians with untreated mildly raised blood pressure. Both basal and...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2010-08, Vol.56 (2), p.253-259
Main Authors: He, Feng J, Marciniak, Maciej, Markandu, Nirmala D, Antonios, Tarek F, MacGregor, Graham A
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Aged
Aldosterone - blood
Arterial hypertension. Arterial hypotension
Asian Continental Ancestry Group
Biological and medical sciences
Blood and lymphatic vessels
Capillaries - anatomy & histology
Capillaries - physiopathology
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diet, Sodium-Restricted
Double-Blind Method
European Continental Ancestry Group
Fingers - blood supply
Hemoglobins - metabolism
Humans
Hypertension - blood
Hypertension - physiopathology
Hypertension - prevention & control
Medical sciences
Microscopy, Video - methods
Middle Aged
Placebos
Polarography - methods
Renin - blood
Skin - blood supply
Systole - physiology
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Summary:Microvascular rarefaction occurs in hypertension. We carried out a 12-week randomized double-blind crossover trial to determine the effect of a modest reduction in salt intake on capillary rarefaction in 71 whites, 69 blacks, and 29 Asians with untreated mildly raised blood pressure. Both basal and maximal (during venous congestion) skin capillary density were measured by capillaroscopy at the dorsum and the side of the fingers. In addition, we used orthogonal polarization spectral imaging to measure skin capillary density at the dorsum of the fingers and the hand web. With a reduction in salt intake from 9.7 to 6.5 g/day, there was an increase in capillary density (capillaries per millimeter squared) from 101±21 to 106±23 (basal) and 108±22 to 115±22 (maximal) at the dorsum, and 101±25 to 107±26 (basal) and 110±26 to 116±26 (maximal) at the side of the fingers (P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.110.155747