Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease: 2-Year Follow-Up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) Study

• Published in: Journal of the American College of Cardiology 2010-07, Vol.56 (3), p.177-184
• Main Authors: PIJLS, Nico H. J, FEARON, William F, OLDROYD, Keith G, VER LEE, Peter N, MACCARTHY, Philip A, DE BRUYNE, Bernard, TONINO, Pim A. L, SIEBERT, Uwe, IKENO, Fumiaki, BORNSCHEIN, Bernhard, VAN'T VEER, Marcel, KLAUSS, Volker, MANOHARAN, Ganesh, ENGSTRØM, Thomas
• Format: Article
• Language: English
• Subjects: Angioplasty, Balloon, Coronary - methods; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular system; Coronary Angiography; Coronary Disease - surgery; Coronary Disease - therapy; Coronary heart disease; Coronary vessels; Diseases of the cardiovascular system; Drug-Eluting Stents; Female; Follow-Up Studies; Fractional Flow Reserve, Myocardial - physiology; Heart; Heart attacks; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Myocardial Infarction - mortality; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Stents; Treatment Outcome
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2010.04.012

The purpose of this study was to investigate the 2-year outcome of percutaneous coronary intervention (PCI) guided by fractional flow reserve (FFR) in patients with multivessel coronary artery disease (CAD). In patients with multivessel CAD undergoing PCI, coronary angiography is the standard method for guiding stent placement. The FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study showed that routine FFR in addition to angiography improves outcomes of PCI at 1 year. It is unknown if these favorable results are maintained at 2 years of follow-up. At 20 U.S. and European medical centers, 1,005 patients with multivessel CAD were randomly assigned to PCI with drug-eluting stents guided by angiography alone or guided by FFR measurements. Before randomization, lesions requiring PCI were identified based on their angiographic appearance. Patients randomized to angiography-guided PCI underwent stenting of all indicated lesions, whereas those randomized to FFR-guided PCI underwent stenting of indicated lesions only if the FFR was