Synthesis of sulfated pectins and their anticoagulant activity

The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfoni...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2010-06, Vol.75 (6), p.759-768
Main Authors: Vityazev, F. V, Golovchenko, V. V, Patova, O. A, Drozd, N. N, Makarov, V. A, Shashkov, A. S, Ovodov, Yu. S
Format: Article
Language:English
Subjects:
Acids
Anticoagulants
Anticoagulants (Medicine)
Anticoagulants - chemistry
Anticoagulants - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Comparative studies
Life Sciences
Magnetic Resonance Spectroscopy
Microbiology
Pectin
Pectins - chemical synthesis
Pectins - chemistry
Pyridine
Reagents
Spectrophotometry, Infrared
Sulfates
Sulfonic Acids - chemistry
Sulfur
Sulfur - chemistry
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Summary:The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfonic acid proved to be the optimal reagent for sulfation of galacturonan and other pectins. Galacturonan and pectin derivatives with different degrees of sulfation were synthesized and their anticoagulant activities were shown to depend on the quantity of sulfate groups in the pectin macromolecules.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297910060118