The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people

• Published in: Rheumatology (Oxford, England) England), 2010-08, Vol.49 (8), p.1461-1465
• Main Authors: Yamagishi, Kazumasa, Tanigawa, Takeshi, Kitamura, Akihiko, Köttgen, Anna, Folsom, Aaron R., Iso, Hiroyasu
• Format: Article
• Language: English
• Subjects: ABCG2; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group - genetics; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Biological and medical sciences; Diseases of the osteoarticular system; Epidemiology; Female; Genetic Predisposition to Disease; Genetics; Gout; Gout - genetics; Gout - metabolism; Humans; Hyperuricemia - genetics; Hyperuricemia - metabolism; Inflammatory joint diseases; Male; Medical sciences; Metabolic diseases; Middle Aged; Miscellaneous. Osteoarticular involvement in other diseases; Multivariate Analysis; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Organic Anion Transporters - genetics; Organic Anion Transporters - metabolism; Other metabolic disorders; Polymorphism; Polymorphism, Single Nucleotide; Purines and pyrimidines (gout, hyperuricemia...); Uric acid; Uric Acid - blood
• ISSN: 1462-0324; 1462-0332
• DOI: 10.1093/rheumatology/keq096

Objectives. Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and Blacks. We examined whether this finding is observed in a Japanese population, since Asians have a high reported prevalence of the T-risk allele. Methods. A total of 3923 Japanese people from the Circulatory Risk in Communities Study aged 40–90 years were genotyped for rs2231142. Associations of the rs2231142 variant with serum uric acid levels and prevalence of gout and hyperuricaemia were examined. Results. The frequency of the T-risk allele was 31% in this Japanese sample. Multivariable adjusted mean uric acid levels were 7–9 μmol/l higher for TG and TT than GG carriers (P-additive = 0.0006). The multivariable-adjusted odds ratio (OR) of prevalent gout was 1.37 (95% CI 0.68, 2.76) for TG and 4.37 (95% CI 1.98, 9.62) for TT compared with the GG carriers (P-additive = 0.001). When evaluating the combined outcome of hyperuricaemia and gout, the respective ORs were 1.40 (95% CI 1.04, 1.87) for TG and 1.88 (95% CI 1.23, 2.89) for TT carriers. The population attributable risk was 29% for gout and 19% for gout and/or hyperuricaemia. Conclusions. The association of the causal ABCG2 rs2231142 variant with uric acid levels and gout was confirmed in a sample of Japanese ancestry. Our study emphasizes the importance of this common causal variant in a population with a high risk allele frequency, especially as more Japanese adopt a Western lifestyle with a concomitant increase in mean serum uric acid levels.