What's in a name? The (mis)labelling of Crohn's as an autoimmune disease

The development of autoimmunity requires, as an initial step, the recognition of self-antigens by antigenspecific autoreactive lymphocytes, followed by their expansion to effector cells that then bring about tissue injury. [...] in the study of autoimmune diseases the aim is to understand how self-t...

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Bibliographic Details
Published in:The Lancet (British edition) 2010-07, Vol.376 (9736), p.202-203
Main Authors: Behr, Marcel A, Dr, Divangahi, Maziar, PhD, Lalande, Jean-Daniel, BSc
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Autoimmune diseases
Autoimmune Diseases - diagnosis
Autoimmunity
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - immunology
Crohn Disease - drug therapy
Crohn Disease - immunology
Humans
Inflammatory bowel disease
Inflammatory Bowel Diseases - drug therapy
Internal Medicine
Lymphocytes
Medical research
Studies
Terminology as Topic
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Summary:The development of autoimmunity requires, as an initial step, the recognition of self-antigens by antigenspecific autoreactive lymphocytes, followed by their expansion to effector cells that then bring about tissue injury. [...] in the study of autoimmune diseases the aim is to understand how self-tolerance collapses, enabling the activation of autoreactive lymphocytes.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(10)60282-6