Electrophysiological manifestations in adults with HIV/AIDS submitted and not submitted to antiretroviral therapy

• Published in: Pró-fono : revista de atualização científica 2010-04, Vol.22 (2), p.107-113
• Main Authors: Matas, Carla Gentile, Silva, Sara Manami, Marcon, Bruna de Almeida, Gonçalves, Isabela Crivellaro
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation; Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - drug therapy; Adolescent; Adult; Antiretroviral Therapy, Highly Active - adverse effects; Audiometry, Pure-Tone; Auditory Diseases, Central - diagnosis; Auditory Diseases, Central - etiology; Case-Control Studies; Event-Related Potentials, P300 - drug effects; Event-Related Potentials, P300 - physiology; Evoked Potentials, Auditory - drug effects; Evoked Potentials, Auditory - physiology; Hearing Loss - diagnosis; Hearing Loss - etiology; HIV Infections - drug therapy; HIV Infections - physiopathology; Humans; Middle Aged; Young Adult
• ISSN: 1809-399X

auditory evoked potentials (AEP) assess the neuroelectric activity on the auditory pathway -from the auditory nerve to the cerebral cortex - in response to an acoustic stimulus or event. Studies have demonstrated electrophysiological abnormalities in individuals with HIV/AIDS. to characterize the hearing electrophysiological manifestations in adults with HIV/AIDS by comparing the results obtained in the group exposed to antiretroviral therapy with those obtained in the group not exposed to such treatment. electrophysiological evaluation of hearing (Auditory Brainstem Response - ABR, Auditory Middle Latency Response - AMLR and P300) was conducted in 56 individuals with HIV/AIDS: 24 participants composed group I (not exposed to antiretroviral treatment) and 32 participants composed group II (exposed to treatment). alterations in every AEP were observed in individuals with HIV/ AIDS, especially in the ABR. Indeed, the group exposed to antiretroviral treatment presented more alterations. individuals with HIV/AIDS may present alterations on the central and peripheral auditory nervous system. The group exposed to antiretroviral therapy presents more alterations on the brainstem auditory pathway.