Renal injury due to hepatic hydatid disease

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 2010-08, Vol.25 (8), p.2611-2615
• Main Authors: Altay, Mustafa, Ünverdi, Selman, Altay, Fatma Aybala, Çeri, Mevlüt, Akay, Hatice, Özer, Hüseyin, Kıraç, Halil, Denizli, Nazım, Yılmaz, Bilal, Güvence, Necmettin, Duranay, Murat
• Format: Article
• Language: English
• Subjects: Adult; Biopsy; Echinococcosis, Hepatic - complications; Female; glomerulonephritis; haematuria; Hematuria - epidemiology; Hematuria - etiology; Humans; hydatid cyst; Kidney - pathology; Kidney Diseases - epidemiology; Kidney Diseases - etiology; Kidney Diseases - pathology; Male; Middle Aged; Prevalence; proteinuria; Proteinuria - epidemiology; Proteinuria - etiology
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfq092

Background. Many studies on renal hydatid disease have been reported in the literature, and the disease process appears to be well defined. However, renal injury without direct renal invasion remains poorly understood. The present study aims to define the frequency and the property of the renal involvement in hydatid disease. Methods. Eighty patients older than 18 years and diagnosed with liver echinococcosis were included in the study. The echinococcosis was diagnosed by the haemagglutination test and abdominal ultrasonography. Twenty-four-hour protein excretion was measured for patients who had elevated serum creatinine levels or whose urinalyses were positive for haematuria or proteinuria. Subsequently, renal biopsy was performed, and the specimens were examined by light microscopy and immunofluorescence staining. Results. Haematuria was detected in 11 patients (13.75%), and proteinuria was detected in nine patients (11.25%). Percutaneous renal biopsy was applied to nine patients who gave signed consents to undergo the test. We detected four immunoglobulin A nephritis (together with tubulointerstitial nephritis in one patient), one membranoproliferative glomerulonephritis, one immunoglobulin M nephritis together with mesangiocapillary glomerulonephritis, one membranous glomerulonephritis, one amyloidosis and one tubulointerstitial nephritis. Renal hydatid cyst was detected only in four patients (5%). Conclusions. Hydatid disease, which affects the kidney, is not rare, and we suggest that urinalysis and, if indicated, renal biopsy should be performed for hepatic hydatid disease diagnosis.