In vitro environmental regulation of Porphyromonas gingivalis growth and virulence

Porphyromonas gingivalis appears to be a major contributor to periodontal disease, especially soft tissue destruction, which is reflected by the ability to cause invasive, spreading lesions, and tissue inflammation in a murine abscess model. This study investigated the role of hemin on the regulatio...

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Bibliographic Details
Published in:Oral Microbiology and Immunology 2003-08, Vol.18 (4), p.226-233
Main Authors: Kesavalu, L., Holt, S. C., Ebersole, J. L.
Format: Article
Language:English
Subjects:
Abscess - microbiology
Adhesins, Bacterial
Animals
Biological and medical sciences
Cysteine Endopeptidases - metabolism
Dentistry
Environment
Fundamental and applied biological sciences. Psychology
growth
Hemagglutinins - metabolism
hemin
Hemin - metabolism
Hemin - pharmacology
Hemin - physiology
iron
Iron - deficiency
Iron - metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Microbiology
Models, Animal
Porphyromonas gingivalis
Porphyromonas gingivalis - growth & development
Porphyromonas gingivalis - metabolism
Porphyromonas gingivalis - pathogenicity
Rabbits
Statistics, Nonparametric
virulence
Virulence - drug effects
Virulence - physiology
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Summary:Porphyromonas gingivalis appears to be a major contributor to periodontal disease, especially soft tissue destruction, which is reflected by the ability to cause invasive, spreading lesions, and tissue inflammation in a murine abscess model. This study investigated the role of hemin on the regulation of growth and virulence of P. gingivalis strains. P. gingivalis strains W50, A7A1‐28, 3079, 381, W50/BEI, and NG4B19 were grown in broth and on blood agar plates. P. gingivalis cells grown under iron‐depleted conditions for multiple passages showed significantly decreased lesion size in mice, in contrast to cells grown under iron‐normal (5 μg/ml) and iron‐elevated conditions. Statistically significant (P 
ISSN:0902-0055
1399-302X
1365-2567
DOI:10.1034/j.1399-302X.2003.00071.x