Duration of Indomethacin Treatment of the Preterm Patent Ductus Arteriosus as Directed by Echocardiography

• Published in: The Journal of pediatrics 2009-12, Vol.155 (6), p.819-822.e1
• Main Authors: Carmo, Kathryn Browning, BMED, FRACP, Evans, Nick, MRCPCH, DM, Paradisis, Mary, MBBS, FRACP
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Cardiovascular system; Cyclooxygenase Inhibitors - administration & dosage; Drug Administration Schedule; Ductus Arteriosus, Patent - diagnostic imaging; Ductus Arteriosus, Patent - drug therapy; Ductus Arteriosus, Patent - surgery; Echocardiography; Female; General aspects; Humans; Indomethacin - administration & dosage; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - diagnostic imaging; Infant, Premature, Diseases - drug therapy; Infant, Premature, Diseases - surgery; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Pediatrics; Pilot Projects; Treatment Outcome; Ultrasonic investigative techniques
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2009.06.013

Objective To determine whether the duration of indomethacin administration could be shortened in infants with good early constrictive response of patent ductus arteriosus (PDA). Study design Infants born at < 30 weeks' gestational age were assessed with echocardiography in the first 12 hours of life and treated with indomethacin (0.1 mg/kg) if the PDA was > 2 mm in diameter. Randomization occurred before the second dose to either standard treatment (2 more doses of indomethacin at 0.1 mg/kg irrespective of echocardiographic findings) or to echocardiographically directed duration of indomethacin treatment (ECHO; further doses only if the PDA was >1.6 mm). Serial echocardiography was performed to day 28 of age. The primary outcome was failure of PDA closure. Results The infants were randomized to either the ECHO arm (n = 34) or the standard treatment arm (n = 40). No differences between the arms were seen in terms of failure of PDA closure, PDA reopening, need for further doses of indomethacin, or need for surgical ligation. More doses of indomethacin were given in the standard treatment arm (median, 3 doses [range, 1 to 12] vs 1 dose [range, 1 to 15]; P < .0001). Conclusion Echocardiographically directed duration of indomethacin treatment is effective in achieving PDA closure and offers the potential for dose minimization.