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Brain stimulation for the treatment of epilepsy
Summary Direct brain stimulation is an emerging treatment of epilepsy. Scheduled or responsive stimulation has been applied. The most explored targets for scheduled stimulation are the anterior nucleus of the thalamus and the hippocampus. The anterior nucleus of the thalamus was studied in a large m...
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| Published in: | Epilepsia (Copenhagen) 2010-07, Vol.51 (s3), p.88-92 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c5148-6192e49c0b8ca0dec3c54e65001ec54a3fb433e2d9ccd818742df8124b112dbe3 |
| container_end_page | 92 |
| container_issue | s3 |
| container_start_page | 88 |
| container_title | Epilepsia (Copenhagen) |
| container_volume | 51 |
| creator | Jobst, Barbara C. Darcey, Terrance M. Thadani, Vijay M. Roberts, David W. |
| description | Summary
Direct brain stimulation is an emerging treatment of epilepsy. Scheduled or responsive stimulation has been applied. The most explored targets for scheduled stimulation are the anterior nucleus of the thalamus and the hippocampus. The anterior nucleus of the thalamus was studied in a large multicenter trial. There was a significant seizure reduction with the stimulator “on” versus “off” during several months after stimulator implantation. The hippocampus as stimulation target has not yet been studied in a large randomized trial. Responsive stimulation applies a stimulus whenever epileptiform activity occurs. It requires on‐line detection of epileptiform activity. This concept is based on the observation that epileptiform activity during functional mapping can be aborted by brief pulses of cortical stimulation. Current technology is able to detect seizure activity intracranially on‐line and delivers a high frequency stimulus if epileptiform activity is detected. A large randomized multicenter trial has been conducted testing this system for focal epilepsy. |
| doi_str_mv | 10.1111/j.1528-1167.2010.02618.x |
| format | article |
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Direct brain stimulation is an emerging treatment of epilepsy. Scheduled or responsive stimulation has been applied. The most explored targets for scheduled stimulation are the anterior nucleus of the thalamus and the hippocampus. The anterior nucleus of the thalamus was studied in a large multicenter trial. There was a significant seizure reduction with the stimulator “on” versus “off” during several months after stimulator implantation. The hippocampus as stimulation target has not yet been studied in a large randomized trial. Responsive stimulation applies a stimulus whenever epileptiform activity occurs. It requires on‐line detection of epileptiform activity. This concept is based on the observation that epileptiform activity during functional mapping can be aborted by brief pulses of cortical stimulation. Current technology is able to detect seizure activity intracranially on‐line and delivers a high frequency stimulus if epileptiform activity is detected. A large randomized multicenter trial has been conducted testing this system for focal epilepsy.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2010.02618.x</identifier><identifier>PMID: 20618409</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Afterdischarges ; Anterior nucleus of the thalamus ; Anterior Thalamic Nuclei - physiopathology ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Brain Mapping ; Deep brain stimulation ; Deep Brain Stimulation - methods ; Epilepsy - physiopathology ; Epilepsy - therapy ; Focal seizures ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampal stimulation ; Hippocampus - physiopathology ; Humans ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Responsive neurostimulation</subject><ispartof>Epilepsia (Copenhagen), 2010-07, Vol.51 (s3), p.88-92</ispartof><rights>Wiley Periodicals, Inc. © 2010 International League Against Epilepsy</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5148-6192e49c0b8ca0dec3c54e65001ec54a3fb433e2d9ccd818742df8124b112dbe3</citedby><cites>FETCH-LOGICAL-c5148-6192e49c0b8ca0dec3c54e65001ec54a3fb433e2d9ccd818742df8124b112dbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23050487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20618409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jobst, Barbara C.</creatorcontrib><creatorcontrib>Darcey, Terrance M.</creatorcontrib><creatorcontrib>Thadani, Vijay M.</creatorcontrib><creatorcontrib>Roberts, David W.</creatorcontrib><title>Brain stimulation for the treatment of epilepsy</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Direct brain stimulation is an emerging treatment of epilepsy. Scheduled or responsive stimulation has been applied. The most explored targets for scheduled stimulation are the anterior nucleus of the thalamus and the hippocampus. The anterior nucleus of the thalamus was studied in a large multicenter trial. There was a significant seizure reduction with the stimulator “on” versus “off” during several months after stimulator implantation. The hippocampus as stimulation target has not yet been studied in a large randomized trial. Responsive stimulation applies a stimulus whenever epileptiform activity occurs. It requires on‐line detection of epileptiform activity. This concept is based on the observation that epileptiform activity during functional mapping can be aborted by brief pulses of cortical stimulation. Current technology is able to detect seizure activity intracranially on‐line and delivers a high frequency stimulus if epileptiform activity is detected. A large randomized multicenter trial has been conducted testing this system for focal epilepsy.</description><subject>Afterdischarges</subject><subject>Anterior nucleus of the thalamus</subject><subject>Anterior Thalamic Nuclei - physiopathology</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Deep brain stimulation</subject><subject>Deep Brain Stimulation - methods</subject><subject>Epilepsy - physiopathology</subject><subject>Epilepsy - therapy</subject><subject>Focal seizures</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampal stimulation</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Responsive neurostimulation</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkD1PwzAQhi0EoqXwF1AWxJT0bOfDGRigKlCpEgwwW45zEanyhZ2I9t_j0FJWvPhkP3f36iHEoxBQd-abgEZM-JTGScDAvQKLqQi2J2R6_DglUwDK_TQSMCEX1m4AIIkTfk4mDBweQjol8wejysazfVkPlerLtvGK1nj9B3q9QdXX2PReW3jYlRV2dndJzgpVWbw63DPy_rh8Wzz765en1eJ-7euIhsKPacowTDVkQivIUXMdhRhHLhG6SvEiCzlHlqda54KKJGR5ISgLM0pZniGfkdv93M60nwPaXtal1VhVqsF2sDLhPE0FZ5EjxZ7UprXWYCE7U9bK7CQFOdqSGzlKkaMUOdqSP7bk1rVeH5YMWY35sfFXjwNuDoCyWlWFUY0u7R_HIYJQJI6723NfztLu3wHk8nU1Vvwbwj2EPw</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Jobst, Barbara C.</creator><creator>Darcey, Terrance M.</creator><creator>Thadani, Vijay M.</creator><creator>Roberts, David W.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Brain stimulation for the treatment of epilepsy</title><author>Jobst, Barbara C. ; Darcey, Terrance M. ; Thadani, Vijay M. ; Roberts, David W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5148-6192e49c0b8ca0dec3c54e65001ec54a3fb433e2d9ccd818742df8124b112dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Afterdischarges</topic><topic>Anterior nucleus of the thalamus</topic><topic>Anterior Thalamic Nuclei - physiopathology</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Deep brain stimulation</topic><topic>Deep Brain Stimulation - methods</topic><topic>Epilepsy - physiopathology</topic><topic>Epilepsy - therapy</topic><topic>Focal seizures</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampal stimulation</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Responsive neurostimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jobst, Barbara C.</creatorcontrib><creatorcontrib>Darcey, Terrance M.</creatorcontrib><creatorcontrib>Thadani, Vijay M.</creatorcontrib><creatorcontrib>Roberts, David W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jobst, Barbara C.</au><au>Darcey, Terrance M.</au><au>Thadani, Vijay M.</au><au>Roberts, David W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain stimulation for the treatment of epilepsy</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2010-07</date><risdate>2010</risdate><volume>51</volume><issue>s3</issue><spage>88</spage><epage>92</epage><pages>88-92</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Direct brain stimulation is an emerging treatment of epilepsy. Scheduled or responsive stimulation has been applied. The most explored targets for scheduled stimulation are the anterior nucleus of the thalamus and the hippocampus. The anterior nucleus of the thalamus was studied in a large multicenter trial. There was a significant seizure reduction with the stimulator “on” versus “off” during several months after stimulator implantation. The hippocampus as stimulation target has not yet been studied in a large randomized trial. Responsive stimulation applies a stimulus whenever epileptiform activity occurs. It requires on‐line detection of epileptiform activity. This concept is based on the observation that epileptiform activity during functional mapping can be aborted by brief pulses of cortical stimulation. Current technology is able to detect seizure activity intracranially on‐line and delivers a high frequency stimulus if epileptiform activity is detected. A large randomized multicenter trial has been conducted testing this system for focal epilepsy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20618409</pmid><doi>10.1111/j.1528-1167.2010.02618.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0013-9580 |
| ispartof | Epilepsia (Copenhagen), 2010-07, Vol.51 (s3), p.88-92 |
| issn | 0013-9580 1528-1167 |
| language | eng |
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| source | Wiley |
| subjects | Afterdischarges Anterior nucleus of the thalamus Anterior Thalamic Nuclei - physiopathology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain Mapping Deep brain stimulation Deep Brain Stimulation - methods Epilepsy - physiopathology Epilepsy - therapy Focal seizures Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampal stimulation Hippocampus - physiopathology Humans Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Responsive neurostimulation |
| title | Brain stimulation for the treatment of epilepsy |
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