Long-term follow-up study of clear cell papulosis

Background Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown. Objectives The aim of this study was to review cases of CCP diagnosed at our institution a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2010-08, Vol.63 (2), p.266-273
Main Authors: Tseng, Fang-Wen, MD, Kuo, Tseng-Tong, MD, PhD, Lu, Pei-Hsuan, MD, Chan, Heng-Leong, MD, Chan, Ming-Jing, MD, Hui, Rosaline Chung-Yee, MD, PhD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoembryonic Antigen - metabolism
Child, Preschool
clear cell papulosis
clear cells of Toker
Dermatology
Disease Progression
extramammary Paget disease
Female
Follow-Up Studies
Humans
Hypopigmentation - metabolism
Hypopigmentation - pathology
Immunohistochemistry
Infant
long-term follow-up
Male
Medical sciences
milk line
Mucin-1 - metabolism
Paget Disease, Extramammary - pathology
Pigmentary diseases of the skin
Remission, Spontaneous
Retrospective Studies
Skin - metabolism
Skin - pathology
Skin Diseases, Papulosquamous - metabolism
Skin Diseases, Papulosquamous - pathology
Staining and Labeling
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown. Objectives The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome. Methods Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed. Results With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density. Limitations Retrospective nature of the study is a limitation. Conclusion No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2009.08.056