Low-frequency electrical stimulation induces long-term depression in patients with chronic tension-type headache

Repetitive low-frequency electrical stimulation (LFS) induces pain inhibition in healthy volunteers and in animals, but it is unknown whether it has an analgesic effect in patients with headache. The aim of this study was to investigate if LFS could induce prolonged pain inhibition, called long-term...

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Bibliographic Details
Published in:Cephalalgia 2010-07, Vol.30 (7), p.860-867
Main Authors: Lindelof, Kim, Jung, Kerstin, Ellrich, Jens, Jensen, Rigmor, Bendtsen, Lars
Format: Article
Language:English
Subjects:
Chronic Disease
Electric Stimulation Therapy - methods
Female
Humans
Long-Term Synaptic Depression - physiology
Male
Pain - etiology
Pain Management
Tension-Type Headache - complications
Tension-Type Headache - therapy
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Summary:Repetitive low-frequency electrical stimulation (LFS) induces pain inhibition in healthy volunteers and in animals, but it is unknown whether it has an analgesic effect in patients with headache. The aim of this study was to investigate if LFS could induce prolonged pain inhibition, called long-term depression (LTD), in patients with chronic tension-type headache (CTTH). Twenty CTTH patients and 20 healthy volunteers were exposed to 20 min LFS (1 Hz) to the forehead. LTD was measured as a decrease in pain response to electrical stimulation in a 1-h post-LFS period following LFS. The LFS induced a significant and stable inhibition of pain (LTD) both in patients with CTTH (post-LFS average decrease in pain rating: 19.6 ± 3.9%, all P 
ISSN:0333-1024
1468-2982
DOI:10.1177/0333102409354783