Distribution of human papillomavirus genotypes among cervical intraepithelial neoplasia and invasive cancers in Macao

• Published in: Journal of medical virology 2010-09, Vol.82 (9), p.1600-1605
• Main Authors: Hlaing, Thazin, Yip, Yuk-Ching, Ngai, Karry L.K, Vong, Heong-Ting, Wong, Sio-In, Ho, Wendy C.S, Batalha, Sellma L.S.C, Chan, Paul K.S
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Asia; cervical intraepithelial neoplasia; Cervical Intraepithelial Neoplasia - epidemiology; Cervical Intraepithelial Neoplasia - virology; China; DNA, Viral - analysis; epidemiology; Female; genotype; human papillomavirus; Humans; invasive cervical cancer; Macao; Macau - epidemiology; Middle Aged; Molecular Epidemiology; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Papillomavirus Vaccines - classification; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - virology; vaccine impact
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.21847

Macao is a densely populated city situated in East Asia where a relatively high prevalence of human papillomavirus (HPV) types 52 and 58 has been reported in women with invasive cervical cancer. To provide data for a population-specific estimation on the impact of HPV vaccines, paraffin-embedded tissues collected from women with invasive cervical cancer or cervical intrapeitheilal neoplasia grade 2 or 3 confirmed histologically were examined for HPV using the INNO-LiPa kit. Of the 35 HPV-positive patients with invasive cancer, one HPV type was detected in 68.6%, and 31.4% were co-infected with more than one HPV type. Overall, HPV 16, HPV 18, HPV 52, and HPV 54 were the most common types found respectively in 57.1%, 17%, 11.4%, and 8.5% of patients with invasive cervical cancer. Among the 59 HPV-positive patients with cervical intraepithelial neoplasia grade 2/3, 55.9% hardbored one HPV type, and 44.1% had co-infections. The common HPV types found included HPV 16 (52.5%), HPV 52 (23.7%), HPV 58 (18.7%), and HPV 33 (17%). Although HPV 11 (a low-risk type) was also found commonly in invasive cervical cancers (14.3%) and cervical intraepithelial neoplasia grade 2/3 (15.3%), the fact that they all existed as co-infections with another high-risk type suggested HPV 11 was not the cause of the lesion. The current vaccines targeting HPV 16/18 are expected to cover 62.9-74.3% of invasive cervical cancers and 32.2-55.9% of cervical intraepithelial neoplasia 2/3 in Macao. Widespread HPV vaccination is expected to reduce substantially the disease burden associated with cervical neoplasia in Macao. J. Med. Virol. 82:1600-1605, 2010.