Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA

1. A luteinizing hormone-releasing hormone (LHRH)-like molecule produced by thymocytes is similar to hypothalamic LHRH in both bioactivity and antigenicity. 2. We determined whether this thymic LHRH is identical to or only homologous with hypothalamic LHRH by synthesizing and sequencing the cDNA of...

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Published in:Cellular and molecular neurobiology 1992-10, Vol.12 (5), p.447-454
Main Authors: Maier, C C, Marchetti, B, LeBoeuf, R D, Blalock, J E
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
DNA - genetics
Female
Gonadotropin-Releasing Hormone - genetics
Hypothalamus - chemistry
Molecular Sequence Data
Pituitary Gland - chemistry
Polymerase Chain Reaction
Rats
Rats, Sprague-Dawley - growth & development
Rats, Sprague-Dawley - metabolism
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Sequence Homology, Nucleic Acid
T-Lymphocytes - metabolism
Thymus Gland - cytology
Thymus Gland - metabolism
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Summary:1. A luteinizing hormone-releasing hormone (LHRH)-like molecule produced by thymocytes is similar to hypothalamic LHRH in both bioactivity and antigenicity. 2. We determined whether this thymic LHRH is identical to or only homologous with hypothalamic LHRH by synthesizing and sequencing the cDNA of rat thymus LHRH. 3. The thymocyte and hypothalamic LHRH cDNAs are identical, indicating, that the amino acid sequences of LHRH produced in the hypothalamus and the immune system are also identical. 4. This is the first report showing conclusively that cell of the immune system transcribe the authentic mRNA for a hypothalamic releasing factor, LHRH.
ISSN:0272-4340
1573-6830
DOI:10.1007/BF00711545