Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety

• Published in: European journal of medicinal chemistry 2010-03, Vol.45 (3), p.1206-1210
• Main Authors: Chandrakantha, B., Shetty, Prakash, Nambiyar, Vijesh, Isloor, Nishitha, Isloor, Arun M.
• Format: Article
• Language: English
• Subjects: 1,3,4-Oxadiazole; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibacterial agents; Antibacterial study; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal study; Bacteria - drug effects; Biological and medical sciences; Fluorine - chemistry; Fungi - drug effects; General aspects; Magnetic Resonance Spectroscopy; Medical sciences; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles - chemical synthesis; Oxadiazoles - chemistry; Oxadiazoles - pharmacology; Pharmacology. Drug treatments; Spectrophotometry, Infrared
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2009.11.046

In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans. In the present investigation, a new series of 1,3,4-oxadiazoles bearing 2-flouro 4-methoxy phenyl moiety were synthesized, characterized and their antimicrobial studies were performed. Few of the compounds showed significant antimicrobial activity. [Display omitted]