Gender differences in platelet aggregation in healthy individuals

This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22–36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hisp...

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Bibliographic Details
Published in:Journal of thrombosis and thrombolysis 2010-08, Vol.30 (2), p.184-191
Main Authors: Otahbachi, Mohammad, Simoni, Jan, Simoni, Grace, Moeller, John F., Cevik, Cihan, Meyerrose, Gary E., Roongsritong, Chanwit
Format: Article
Language:English
Subjects:
Adenosine Diphosphate
Adult
African Americans
Arachidonic Acid
Cardiology
Collagen
Epinephrine
European Continental Ancestry Group
Female
Hematology
Hispanic Americans
Humans
Male
Medicine
Medicine & Public Health
Platelet Aggregation
Platelet Function Tests
Reference Values
Sex Factors
Texas
Young Adult
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Summary:This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22–36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hispanic origin. In this ex-vivo study, we investigated platelet aggregation in response to adenosine-5′-diphosphate (ADP), epinephrine (EPI), arachidonic acid (AA) and collagen (COL), using a platelet ionized calcium aggregometer (Chrono-Log Co.). Platelet aggregation response to all tested agonists was higher in females than in males regardless of ethnicity. The most significant differences were observed with collagen ( P  
ISSN:0929-5305
1573-742X
DOI:10.1007/s11239-009-0436-x