Outcomes of Routine Use of Antibiotic-Loaded Cement in Primary Total Knee Arthroplasty

Abstract The routine use of antibiotic-loaded bone cement (ALBC) in primary total knee arthroplasty (TKA) is controversial. Outcomes were recorded in patients who underwent primary TKA from May 2003 to March 2007 using a community-based total joint registry. Infection rates were compared in patients...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of arthroplasty 2009-09, Vol.24 (6), p.44-47
Main Authors: Namba, Robert S., MD, Chen, Yuexin, BS, Paxton, Elizabeth W., MA, Slipchenko, Tamara, PhD, Fithian, Donald C., MD
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Antibiotic Prophylaxis
antibiotic-loaded cement
Arthroplasty, Replacement, Knee - methods
Bone Cements
Cohort Studies
Drug Delivery Systems - methods
Female
Humans
infection rate
Knee Prosthesis
Male
Models, Statistical
Multivariate Analysis
Orthopedics
primary total knee arthroplasty
Prosthesis-Related Infections - prevention & control
Registries
Retrospective Studies
Selection Bias
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The routine use of antibiotic-loaded bone cement (ALBC) in primary total knee arthroplasty (TKA) is controversial. Outcomes were recorded in patients who underwent primary TKA from May 2003 to March 2007 using a community-based total joint registry. Infection rates were compared in patients undergoing TKA with ALBC and regular cement. A total of 22 889 primary TKA were performed, with 2030 cases (8.9%) using ALBC. Two thousand four hundred forty-nine patients were diabetic (10.7%), with ALBC used in 295 cases (12%). The rate of deep infection was 1.4% for ALBC TKA (28 cases) and 0.7% (154 cases) with regular cement ( P = .002). Among patients with diabetes, the infection rate was 1.7% (5 cases) with ALBC and 0.9% (19 cases) with regular cement ( P = .199). In patients whom surgeons considered higher risk for infection, ALBC did not appear to reduce TKA infection rates. The routine use of antibiotic-laden cement warrants further investigation.
ISSN:0883-5403
1532-8406
DOI:10.1016/j.arth.2009.05.007