Nonbacterial thrombotic endocarditis complicated with stage Ia ovarian cancer

Nonbacterial thrombotic endocarditis (NBTE) commonly occurs in advanced malignancies associated with a cancer-related hypercoagulable state, but the prevalence of NBTE in patients with less advanced malignancies is unknown. A 46-year-old woman had multiple thromboembolic events and disseminated intr...

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Bibliographic Details
Published in:International journal of clinical oncology 2009-08, Vol.14 (4), p.369-371
Main Authors: Tanaka, Hirohiko, Ito, Masako, Yoshida, Kayo, Asakura, Tetsuo, Taniguchi, Haruki
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Anticoagulants - therapeutic use
Autopsy
Blood Coagulation
Cancer Research
Case Report
Case studies
Coronary vessels
Disseminated Intravascular Coagulation - blood
Disseminated Intravascular Coagulation - drug therapy
Disseminated Intravascular Coagulation - etiology
Echocardiography
Endocarditis - blood
Endocarditis - drug therapy
Endocarditis - etiology
Fatal Outcome
Female
Humans
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Middle Aged
Necrosis
Neoplasm Staging
Oncology
Ovarian cancer
Ovarian Neoplasms - blood
Ovarian Neoplasms - complications
Ovarian Neoplasms - pathology
Surgical Oncology
Thromboembolism - blood
Thromboembolism - drug therapy
Thromboembolism - etiology
Thrombosis
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Summary:Nonbacterial thrombotic endocarditis (NBTE) commonly occurs in advanced malignancies associated with a cancer-related hypercoagulable state, but the prevalence of NBTE in patients with less advanced malignancies is unknown. A 46-year-old woman had multiple thromboembolic events and disseminated intravascular coagulation on admission. Transthoracic echocardiography showed several growths on the mitral valve. Pelvic magnetic resonance imaging revealed a rapidly enlarging large tumor. In spite of anticoagulation therapy, she died 1.5 months after admission. At autopsy, NBTE with stage Ia ovarian cancer was diagnosed. In cases of higher-growth rate tumors with abundant necrosis, NBTE may occur in early-stage (even in stage Ia) ovarian cancer. In the majority of stage Ia ovarian cancers, curative surgical resection can be done. Prognostic improvement may be gained by such positive intervention, although this depends on the patient’s general condition when NBTE occurs. With tumor resection, there is a possibility that the patient will recover from the hypercoagulable state and a poor outcome will be avoided.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-008-0852-5