Tenascins and their implications in diseases and tissue mechanics

Tenascins are glycoproteins found in the extracellular matrix (ECM) of many tissues. Their role is not only to support the tissue structurally but also to regulate the fate of the different cell types populating the ECM. For instance, tenascins are required when active tissue modeling during embryog...

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Bibliographic Details
Published in:Scandinavian journal of medicine & science in sports 2009-08, Vol.19 (4), p.511-519
Main Authors: Brellier, F., Tucker, R. P., Chiquet-Ehrismann, R.
Format: Article
Language:English
Subjects:
asthma
Asthma - metabolism
Biomechanical Phenomena
cancer
Connective Tissue - metabolism
Disease
Ehlers Danlos
Ehlers-Danlos Syndrome - metabolism
Extracellular Matrix - metabolism
Glycoproteins
Humans
inflammation
Neoplasms - metabolism
Tenascin - metabolism
Tissues
tumor stroma
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Summary:Tenascins are glycoproteins found in the extracellular matrix (ECM) of many tissues. Their role is not only to support the tissue structurally but also to regulate the fate of the different cell types populating the ECM. For instance, tenascins are required when active tissue modeling during embryogenesis or re‐modeling after injury occurs. Interestingly, the four members of the tenascin family, tenascin‐C, ‐X, ‐R and ‐W, show different and often mutually exclusive expression patterns. As a consequence, these structurally related proteins display distinct functions and are associated with distinct pathologies. The present review aims at presenting the four members of the tenascin family with respect to their structure, expression patterns and implications in diseases and tissue mechanics.
ISSN:0905-7188
1600-0838
DOI:10.1111/j.1600-0838.2009.00916.x