Effects of uremic toxins on vascular and bone remodeling

Chronic kidney disease (CKD) is associated with both extensive vascular calcification and abnormal bone remodeling, namely renal osteodystrophy. Moreover, there is increasing evidence for a close relationship between bone and vessel function. Pathological vascular calcification has been recently rec...

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Bibliographic Details
Published in:Seminars in dialysis 2009-07, Vol.22 (4), p.433-437
Main Authors: Barreto, Fellype C, Barreto, Daniela V, Liabeuf, Sophie, Drüeke, Tilman B, Massy, Ziad A
Format: Article
Language:English
Subjects:
Bone Demineralization, Pathologic - etiology
Bone Remodeling - physiology
Calcinosis - etiology
Humans
Toxins, Biological - physiology
Uremia - complications
Uremia - metabolism
Uremia - physiopathology
Vascular Diseases - etiology
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Summary:Chronic kidney disease (CKD) is associated with both extensive vascular calcification and abnormal bone remodeling, namely renal osteodystrophy. Moreover, there is increasing evidence for a close relationship between bone and vessel function. Pathological vascular calcification has been recently recognized as an active, cell-mediated process with similarities to physiological skeletal mineralization. Accordingly, we described the concept of vascular remodeling, in analogy to bone remodeling. In this review, we discuss the role of uremic toxins in the cross-talk between bone and vessel, and emphasize their potential contribution to the development of both vascular and bone remodeling disorders in patients with CKD.
ISSN:0894-0959
1525-139X
DOI:10.1111/j.1525-139X.2009.00595.x