Magnolol enhances pentobarbital-induced sleeping behaviors: possible involvement of GABAergic systems

This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The e...

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Bibliographic Details
Published in:Phytotherapy research 2009-09, Vol.23 (9), p.1340-1344
Main Authors: Ma, Hong, Kim, Chung-Soo, Ma, Yuan, Nam, Sang-Yoon, Kim, Dong-Seon, Woo, Sung-Sick, Hong, Jin-Tae, Oh, Ki-Wan
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biphenyl Compounds - isolation & purification
Biphenyl Compounds - pharmacology
Cells, Cultured
Cerebellum - cytology
chloride influx
Chlorides - metabolism
GABAA receptors
General pharmacology
Glutamate Decarboxylase - metabolism
glutamic acid decarboxylase (GAD)
Lignans - isolation & purification
Lignans - pharmacology
Magnolia - chemistry
magnolol
Male
Medical sciences
Mice
Mice, Inbred ICR
Molecular Structure
pentobarbital
Pentobarbital - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Receptors, GABA-A - metabolism
sleep
Sleep - drug effects
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Summary:This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABAA receptor α-subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of β- or γ-subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital-induced sleeping behaviors through the activation of GABAergic systems. Copyright © 2009 John Wiley '' Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2773