Association between carotid diameter and the advanced glycation end product N-epsilon-carboxymethyllysine (CML)

Nepsilon-carboxymethyllysine (CML) is the major non-cross linking advanced glycation end product (AGE). CML is elevated in diabetic patients and apparent in atherosclerotic lesions. AGEs are associated with hypertension and arterial stiffness potentially by qualitative changes of elastic fibers. We...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular diabetology 2009-08, Vol.8, p.45-45
Main Authors: Baumann, Marcus, Richart, Tom, Sollinger, Daniel, Pelisek, Jaroslav, Roos, Marcel, Kouznetsova, Tatiana, Eckstein, Hans-Henning, Heemann, Uwe, Staessen, Jan A
Format: Article
Language:English
Subjects:
Adult
alpha-2-HS-Glycoprotein
Anthropometry
Belgium - epidemiology
Biomarkers
Blood Proteins - analysis
Carotid Arteries - chemistry
Carotid Arteries - diagnostic imaging
Carotid Arteries - ultrastructure
Carotid Artery Diseases - blood
Carotid Artery Diseases - complications
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - pathology
Carotid Artery Diseases - surgery
Cohort Studies
Elasticity
Female
Glycation End Products, Advanced - blood
Humans
Hypertension - complications
Inflammation
Lysine - analogs & derivatives
Lysine - blood
Male
Mechanotransduction, Cellular
Middle Aged
Sampling Studies
Tunica Intima - ultrastructure
Ultrasonography
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nepsilon-carboxymethyllysine (CML) is the major non-cross linking advanced glycation end product (AGE). CML is elevated in diabetic patients and apparent in atherosclerotic lesions. AGEs are associated with hypertension and arterial stiffness potentially by qualitative changes of elastic fibers. We investigated whether CML affects carotid and aortic properties in normoglycemic subjects. Hundred-two subjects (age 48.2+/-11.3 years) of the FLEMENGHO study were stratified according to the median of the plasma CML level (200.8 ng/ml; 25th percentile: 181.6 ng/ml, 75th percentile: 226.1 ng/ml) into "high CML" versus "low CML" as determined by ELISA. Local carotid artery properties, carotid intima media thickness (IMT), aortic pulse wave velocity (PWV), blood pressure and fetuin-A were analyzed. In 26 patients after carotidectomy, CML was visualized using immunohistochemistry. According to the CML median, groups were similar for anthropometric and biochemical data. Carotid diameter was enlarged in the "high" CML group (485.7+/-122.2 versus 421.2+/-133.2 microm; P
ISSN:1475-2840
DOI:10.1186/1475-2840-8-45