Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil

Extramedullary plasmacytoma (EP) is characterized by a neoplastic proliferation of plasma cells in a soft tissue site and arises particularly in the head and neck region. We report here an unusual case of maxillary sinus EP coexisting with oral squamous cell carcinoma (SCC) in a patient without any...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2009-09, Vol.108 (3), p.413-416
Main Authors: Junquera, Luis, MD, DDS, PhD, Gallego, Lorena, MD, DDS, Torre, Aintzane, MD, DDS, Hernando, Josué, MD, Fresno, Manuel F., MD, PhD
Format: Article
Language:English
Subjects:
ADP-ribosyl Cyclase 1 - analysis
Antigens, CD19 - analysis
Biological and medical sciences
Carcinoma, Squamous Cell - pathology
Dentistry
Hematologic and hematopoietic diseases
Humans
Immunoglobulin kappa-Chains - analysis
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocyte Common Antigens - analysis
Male
Maxillary Sinus Neoplasms - pathology
Medical sciences
Middle Aged
Mouth Neoplasms - pathology
Neoplasms, Multiple Primary - pathology
Otorhinolaryngology. Stomatology
Plasmacytoma - pathology
Plasmacytoma - secondary
Skin Neoplasms - secondary
Surgery
Syndecan-1 - analysis
Thoracic Neoplasms - secondary
Tonsillar Neoplasms - pathology
Tonsillar Neoplasms - secondary
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Extramedullary plasmacytoma (EP) is characterized by a neoplastic proliferation of plasma cells in a soft tissue site and arises particularly in the head and neck region. We report here an unusual case of maxillary sinus EP coexisting with oral squamous cell carcinoma (SCC) in a patient without any identified environmental risk or predisposing factors. The maxillary sinus mass proved to be radioresistant, with distant metastasis of EP in the tonsil and thoracic skin. The patient subsequently received chemotherapy and showed no evidence of recurrence at 6 months' follow-up. To the best of our knowledge, this is the first case reported demonstrating synchronous occurrence of oral SCC and EP arising in oral cavity.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2009.03.048