Lack of functional relevance of isolated cell damage in transplants of Parkinson’s disease patients

Postmortem analyses from clinical neural transplantation trials of several subjects with Parkinson’s disease revealed surviving grafted dopaminergic neurons after more than a decade. A subset of these subjects displayed isolated dopaminergic neurons within the grafts that contained Lewy body-like st...

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Bibliographic Details
Published in:Journal of neurology 2009-08, Vol.256 (Suppl 3), p.310-316
Main Authors: Cooper, Oliver, Astradsson, Arnar, Hallett, Penny, Robertson, Harold, Mendez, Ivar, Isacson, Ole
Format: Article
Language:English
Subjects:
Brain Tissue Transplantation - methods
Cell Culture Techniques
Drug therapy
Fetal Tissue Transplantation - methods
Graft Survival - physiology
Humans
Lewy Bodies - metabolism
Lewy Bodies - pathology
Medicine
Medicine & Public Health
Nerve Degeneration - pathology
Nerve Degeneration - physiopathology
Neurology
Neuroradiology
Neurosciences
Parkinson Disease - pathology
Parkinson Disease - physiopathology
Parkinson Disease - surgery
Parkinson's disease
Pathology
Patients
Recovery (Medical)
Substantia Nigra - transplantation
Transplants & implants
Treatment Outcome
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Summary:Postmortem analyses from clinical neural transplantation trials of several subjects with Parkinson’s disease revealed surviving grafted dopaminergic neurons after more than a decade. A subset of these subjects displayed isolated dopaminergic neurons within the grafts that contained Lewy body-like structures. In this review, we discuss why this isolated cell damage is unlikely to affect the overall graft function and how we can use these observations to help us to understand age-related neurodegeneration and refine our future cell replacement therapies.
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-009-5242-z