Thermosensitive PEG–PCL–PEG Hydrogel Controlled Drug Delivery System: Sol–Gel–Sol Transition and In Vitro Drug Release Study

In this article, biodegradable and low molecular weight poly(ethylene glycol)–poly(ε-caprolactone)–poly(ethylene glycol) (PEG–PCL–PEG, PECE) triblock copolymers were successfully synthesized. Aqueous solution of the obtained PECE copolymers underwent sol–gel–sol transition as temperature increased w...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2009-10, Vol.98 (10), p.3707-3717
Main Authors: Gong, Chang Yang, Dong, Peng Wei, Shi, Shuai, Fu, Shao Zhi, Yang, Jin Liang, Guo, Gang, Zhao, Xia, Wei, Yu Quan, Qian, Zhi Yong
Format: Article
Language:English
Subjects:
Acids - chemistry
biodegradable polymers
Biological and medical sciences
Chromatography, Gel
Delayed-Action Preparations
Drug Delivery Systems
drug release
General pharmacology
Hot Temperature
hydrogel
Hydrogels - chemistry
Hydrogen-Ion Concentration
injectable
Magnetic Resonance Spectroscopy
Medical sciences
Microscopy, Electron, Scanning
Molecular Weight
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyesters - chemistry
Polyethylene Glycols - chemistry
protein delivery
Rheology
Serum Albumin, Bovine - administration & dosage
Serum Albumin, Bovine - chemistry
Sodium Chloride - chemistry
sol-gel-sol transition
Spectroscopy, Fourier Transform Infrared
Temperature
thermosensitive
Vitamin B 12 - administration & dosage
Vitamin B 12 - chemistry
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Summary:In this article, biodegradable and low molecular weight poly(ethylene glycol)–poly(ε-caprolactone)–poly(ethylene glycol) (PEG–PCL–PEG, PECE) triblock copolymers were successfully synthesized. Aqueous solution of the obtained PECE copolymers underwent sol–gel–sol transition as temperature increased which was flowing sol at room temperature and then turned into nonflowing gel at body temperature. Sol–gel–sol phase transition behaviors of aqueous PECE solutions were studied using rheometry and test tube-inverting method, which were affected by many factors, including the heating/cooling procedure and different additives in copolymers aqueous solution. In vitro drug release behavior was studied using bovine serum albumin (BSA) and Vitamin B12 (VB12) as model drugs, and the PECE hydrogel could protect BSA from acidic degradation for 1 week at least. Therefore, PECE hydrogel is believed to be promising for injectable in situ gel-forming controlled drug delivery system due to their great thermosensitivity and biodegradability. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3707–3717, 2009
ISSN:0022-3549
1520-6017
1520-6017
DOI:10.1002/jps.21694