Efficacy of a hypofractionated schedule in electron beam radiotherapy for epithelial skin cancer: Analysis of 434 cases

Abstract Background and purpose Efficacy of radiotherapy for epithelial skin cancer was evaluated and treatment outcomes of two electron beam fractionation schedules were compared. Materials and methods Outcome data of 434 epithelial skin cancers in 333 patients were analysed; 332 were basal cell ca...

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Published in:Radiotherapy and oncology 2010-05, Vol.95 (2), p.245-249
Main Authors: van Hezewijk, Marjan, Creutzberg, Carien L, Putter, Hein, Chin, Alim, Schneider, Irmhild, Hoogeveen, Mascha, Willemze, Rein, Marijnen, Corrie A.M
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Carcinoma, Basal Cell - radiotherapy
Carcinoma, Squamous Cell - radiotherapy
Dose Fractionation
Electron beam irradiation
Epithelial skin cancer
Female
Hematology, Oncology and Palliative Medicine
Humans
Local control
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasms, Glandular and Epithelial - radiotherapy
Prognostic factors
Radiotherapy
Skin Neoplasms - radiotherapy
Treatment Outcome
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Summary:Abstract Background and purpose Efficacy of radiotherapy for epithelial skin cancer was evaluated and treatment outcomes of two electron beam fractionation schedules were compared. Materials and methods Outcome data of 434 epithelial skin cancers in 333 patients were analysed; 332 were basal cell carcinomas (BCCs) and 102 squamous cell carcinomas (SCCs). Patients were treated with electron beam, and received either 54 Gy in 18 fractions ( n = 159) or 44 Gy in 10 fractions ( n = 275). Local recurrence free (LRF) rates were analysed as well as metastases free rates, cancer specific survival (CSS) and cosmetic result. Results Median follow-up was 42.8 months. For BCC, actuarial 3-year LRF rates were 97.6% for tumours treated with 54 Gy and 96.9% for 44 Gy. In SCC 3-year LRF rates were 97.0% for 54 Gy and 93.6% for 44 Gy (n.s.). T stage was found to be the only significant factor for recurrence ( p = 0.036). Three-year CSS was 98% for SCC and 100% for BCC. Conclusions Electron beam irradiation is a safe and effective treatment modality for epithelial skin cancer. In view of a similar efficacy and patient convenience of the hypofractionated schedule, 44 Gy in 10 fractions can be regarded the radiation schedule of choice.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2010.02.024