Specification of DNA binding activity of NF-kappaB proteins

Nuclear factor-kappaB (NF-kappaB) is a pleiotropic mediator of inducible and specific gene regulation involving diverse biological activities including immune response, inflammation, cell proliferation, and death. The fine-tuning of the NF-kappaB DNA binding activity is essential for its fundamental...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2009-10, Vol.1 (4), p.a000067-a000067
Main Authors: Wan, Fengyi, Lenardo, Michael J
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - metabolism
Chromatin - chemistry
DNA - chemistry
Gene Expression Regulation
Humans
Models, Biological
NF-kappa B - metabolism
Nuclear Proteins - metabolism
Protein Binding
Transcription Factor RelA - metabolism
Transcription Factors - metabolism
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Summary:Nuclear factor-kappaB (NF-kappaB) is a pleiotropic mediator of inducible and specific gene regulation involving diverse biological activities including immune response, inflammation, cell proliferation, and death. The fine-tuning of the NF-kappaB DNA binding activity is essential for its fundamental function as a transcription factor. An increasing body of literature illustrates that this process can be elegantly and specifically controlled at multiple levels by different protein subsets. In particular, the recent identification of a non-Rel subunit of NF-kappaB itself provides a new way to understand the selective high-affinity DNA binding specificity of NF-kappaB conferred by a synergistic interaction within the whole complex. Here, we review the mechanism of the specification of DNA binding activity of NF-kappaB complexes, one of the most important aspects of NF-kappaB transcriptional control.
ISSN:1943-0264
DOI:10.1101/cshperspect.a000067