Controlling Peptide Structure with Coordination Chemistry: Robust and Reversible Peptide–Dirhodium Ligation

Mild and reversible: A dirhodium tetracarboxylate reacts with peptides to bridge carboxylate side chains (see scheme). The ligation proceeds under mild aqueous conditions and is readily reversible. Dirhodium adduct formation can be used to control the conformation and supramolecular structure of pep...

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Bibliographic Details
Published in:Chemistry : a European journal 2009-09, Vol.15 (36), p.8961-8965
Main Authors: Zaykov, Alexander N., MacKenzie, Kevin R., Ball, Zachary T.
Format: Article
Language:English
Subjects:
bioinorganic chemistry
Ligation
Macrocyclic Compounds - chemistry
metalloproteins
Metalloproteins - chemical synthesis
Metalloproteins - chemistry
Models, Molecular
Molecular Conformation
Organometallic Compounds - chemistry
peptides
Peptides - chemistry
rhodium
Rhodium - chemistry
supramolecular chemistry
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Summary:Mild and reversible: A dirhodium tetracarboxylate reacts with peptides to bridge carboxylate side chains (see scheme). The ligation proceeds under mild aqueous conditions and is readily reversible. Dirhodium adduct formation can be used to control the conformation and supramolecular structure of peptides.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200901266