A Simple and Efficient Catalytic System for N‐Arylation of Imidazoles in Water

N‐Arylation in water! A simple and highly efficient protocol for the N‐arylation of imidazoles with aryl halides in water catalyzed by a sulfonato–Cu(salen) complex (see scheme) has been developed. This novel strategy requires only mild reaction conditions and has excellent functional‐group toleranc...

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Bibliographic Details
Published in:Chemistry : a European journal 2009-09, Vol.15 (36), p.8971-8974
Main Authors: Wang, Yi, Wu, Zhiqing, Wang, Lixia, Li, Zhengkai, Zhou, Xiangge
Format: Article
Language:English
Subjects:
Catalysis
copper
Copper - chemistry
Cross-Linking Reagents - chemistry
cross‐coupling
homogeneous catalysis
Imidazoles - chemistry
Molecular Structure
Organometallic Compounds - chemistry
sulfonates
Water
water chemistry
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Summary:N‐Arylation in water! A simple and highly efficient protocol for the N‐arylation of imidazoles with aryl halides in water catalyzed by a sulfonato–Cu(salen) complex (see scheme) has been developed. This novel strategy requires only mild reaction conditions and has excellent functional‐group tolerance. The water‐soluble catalyst can be recovered easily and reused at least three times without obvious detriment to the catalytic abilities.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200901232