Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis

Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectrosco...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2009-09, Vol.11 (18), p.4120-4123
Main Authors: Geng, Chang-An, Jiang, Zhi-Yong, Ma, Yun-Bao, Luo, Jie, Zhang, Xue-Mei, Wang, Hong-Ling, Shen, Yong, Zuo, Ai-Xue, Zhou, Jun, Chen, Ji-Jun
Format: Article
Language:English
Subjects:
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Drugs, Chinese Herbal - chemistry
Hepatitis B Surface Antigens - chemistry
Hepatitis C Antigens - chemistry
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Molecular Structure
Structure-Activity Relationship
Swertia - chemistry
X-Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC50 values of 3.66 and 3.58 mM, respectively.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol901592f