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Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis
Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectrosco...
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| Published in: | Organic letters 2009-09, Vol.11 (18), p.4120-4123 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a380t-cc988a155e7e5190dc0c3b50636c8d5931b419af74d07dd692d916aa273a853 |
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| cites | cdi_FETCH-LOGICAL-a380t-cc988a155e7e5190dc0c3b50636c8d5931b419af74d07dd692d916aa273a853 |
| container_end_page | 4123 |
| container_issue | 18 |
| container_start_page | 4120 |
| container_title | Organic letters |
| container_volume | 11 |
| creator | Geng, Chang-An Jiang, Zhi-Yong Ma, Yun-Bao Luo, Jie Zhang, Xue-Mei Wang, Hong-Ling Shen, Yong Zuo, Ai-Xue Zhou, Jun Chen, Ji-Jun |
| description | Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC50 values of 3.66 and 3.58 mM, respectively. |
| doi_str_mv | 10.1021/ol901592f |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2009-09, Vol.11 (18), p.4120-4123 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734042734 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Drugs, Chinese Herbal - chemistry Hepatitis B Surface Antigens - chemistry Hepatitis C Antigens - chemistry Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Molecular Structure Structure-Activity Relationship Swertia - chemistry X-Rays |
| title | Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis |
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