An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

Molecularly imprinted polymers (MIPs) were applied as molecular recognition elements to an electrochemical sensor for phenylephrine. A MIPs membrane was created on a glassy carbon electrode. SEM revealed a gradual change on the morphology of modified electrodes as the ratios of function monomer and...

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Bibliographic Details
Published in:Analytical Sciences 2009/09/10, Vol.25(9), pp.1089-1093
Main Authors: YAO, Liuduan, TANG, Youwen, ZENG, Weipeng, HUANG, Zhaofa
Format: Article
Language:English
Subjects:
Adsorption
Analytical Chemistry
Carbon - chemistry
Chemistry
Chemistry, Analytic - economics
Chemistry, Analytic - instrumentation
Electrochemistry
Electrodes
Glass - chemistry
Membranes, Artificial
Molecular Imprinting
Oxidation-Reduction
Phenylephrine - analysis
Phenylephrine - chemistry
Polymers - chemistry
Surface Properties
Tablets - chemistry
Time Factors
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Summary:Molecularly imprinted polymers (MIPs) were applied as molecular recognition elements to an electrochemical sensor for phenylephrine. A MIPs membrane was created on a glassy carbon electrode. SEM revealed a gradual change on the morphology of modified electrodes as the ratios of function monomer and cross-linking varied. When the ratio was 4:40, the surface morphology between the imprinted electrode (M-electrode) and the control electrode (N-electrode) became unambiguously different. This artificial receptor exhibited high selectivity for the template compared to closely related analogue. The response of the sensor varied in different concentration range might due to the heterogeneity of the MIPs membrane. This sensor was also used to determine phenylephrine in tablet samples.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.25.1089