Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects

Schizophrenia is a complex disorder with a high heritability. Family members have an increased risk not only for schizophrenia per se but also for schizophrenia spectrum disorders. Impairment of neuropsychological functions found in schizophrenia patients are also frequently observed in their relati...

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Bibliographic Details
Published in:Psychological medicine 2009-10, Vol.39 (10), p.1657-1665
Main Authors: Kircher, T., Markov, V., Krug, A., Eggermann, T., Zerres, K., Nöthen, M. M., Skowronek, M. H., Rietschel, M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Carrier Proteins - genetics
Cognition
Cognition & reasoning
Dysbindin
Dystrophin-Associated Proteins
Female
Genes
Genetic variation
Genotype
Genotype & phenotype
Heredity
Humans
Male
Medical sciences
Middle Aged
Neuropsychological Tests
P1578
Personality
Personality - genetics
Personality disorders
Personality Inventory
Personality traits
Polymorphism, Single Nucleotide
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Relatives
rs1018381
Schizophrenia
Schizophrenia - genetics
schizotypy
Young Adult
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Summary:Schizophrenia is a complex disorder with a high heritability. Family members have an increased risk not only for schizophrenia per se but also for schizophrenia spectrum disorders. Impairment of neuropsychological functions found in schizophrenia patients are also frequently observed in their relatives. The dystrobrevin-binding protein 1 (DTNBP1) gene located at chromosome 6p22.3 is one of the most often replicated vulnerability genes for schizophrenia. In addition, this gene has been shown to modulate general cognitive abilities both in healthy subjects and in patients with schizophrenia. In a sample of 521 healthy subjects we investigated an association between the DTNBP1 genotype [single nucleotide polymorphism (SNP) rs1018381], personality traits [using the NEO Five-Factor Inventory (NEO-FFI) and the Schizotypal Personality Questionnaire - Brief Version (SPQ-B)] and cognitive function (estimated IQ, verbal fluency, attention, working memory and executive function). Significantly lower scores on the SPQ-B (p=0.0005) and the Interpersonal Deficit subscale (p=0.0005) in carriers of the A-risk allele were detected. There were no differences in any of the cognitive variables between groups. The results indicate that genetic variation of the DTNBP1 genotype might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291709005388