Correlation of olfactory dysfunction of different etiologies in MRI and comparison with subjective and objective olfactometry

Abstract Background The clinical diagnosis of olfactory dysfunction of different etiologies has been standardized by the German Working Group of Olfactology and Gustology, but there is no agreement about the most suitable imaging modality for diagnosing this disorder. Material and methods A total of...

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Bibliographic Details
Published in:European journal of radiology 2009-09, Vol.71 (3), p.469-473
Main Authors: Goektas, Oender, Fleiner, Franca, Sedlmaier, Benedikt, Bauknecht, Christian
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Electroencephalography - methods
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
MRI
Nervous system
Nervous system (semeiology, syndromes)
Neurology
Objective olfactometry
Olfaction Disorders - diagnosis
Olfactory bulb
Olfactory Bulb - pathology
Olfactory dysfunction
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiology
Reproducibility of Results
Sensitivity and Specificity
Sensory Thresholds
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Summary:Abstract Background The clinical diagnosis of olfactory dysfunction of different etiologies has been standardized by the German Working Group of Olfactology and Gustology, but there is no agreement about the most suitable imaging modality for diagnosing this disorder. Material and methods A total of 24 patients (13 women, 11 men; mean age 52 years) with different types of olfactory dysfunction (anosmia, hyposmia) were examined by objective and subjective olfactometry and magnetic resonance imaging (MRI) of the olfactory bulb. Results There was a positive correlation between objective olfactometry and volumetry of the olfactory bulb but no correlation between subjective olfactometry and MRI. Conclusion MRI allows an evaluation of the olfactory bulb and appears to be superior to other modalities such as computed tomography (CT). Objective olfactometry remains the gold standard for reliable diagnosis of olfactory dysfunction.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2008.10.039