Two New Alkaloids from Xestospongia sp., a New Caledonian Sponge

Five alkaloids have been isolated from a New Caledonian sponge Xestospongia sp. These include three known xestospongin derivatives, the new demethylxestospongin B (1) and a tetrahydrocarboline derivative 5. The structures of the new compounds 1 and 5 have been established by nmr studies and comparis...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1992-10, Vol.55 (10), p.1505-1508
Main Authors: Quirion, Jean-Charks, Sevenet, Thierry, Husson, Henri-Philippe, Weniger, Bernard, Debitus, Cécile
Format: Article
Language:English
Subjects:
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Antineoplastic Agents - pharmacology
Biological and medical sciences
General pharmacology
Humans
KB Cells - drug effects
Leukemia L1210 - drug therapy
Leukemia P388 - drug therapy
Macrocyclic Compounds
Magnetic Resonance Spectroscopy
Medical sciences
Oxazoles
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Tumor Cells, Cultured
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Summary:Five alkaloids have been isolated from a New Caledonian sponge Xestospongia sp. These include three known xestospongin derivatives, the new demethylxestospongin B (1) and a tetrahydrocarboline derivative 5. The structures of the new compounds 1 and 5 have been established by nmr studies and comparison with previously described products.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50088a017