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Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes
Aim: Capsular polysaccharides play an important role in the virulence of Gram‐positive and Gram‐negative bacteria. In Porphyromonas gingivalis, six serotypes have been described based on capsular antigenicity and its pathogenicity has been correlated both in vitro and in animal models. This study ai...
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| Published in: | Journal of clinical periodontology 2009-10, Vol.36 (10), p.823-829 |
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| container_issue | 10 |
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| container_title | Journal of clinical periodontology |
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| creator | Vernal, Rolando León, Rubén Silva, Augusto Van Winkelhoff, Arie J. Garcia-Sanz, Jose A. Sanz, Mariano |
| description | Aim: Capsular polysaccharides play an important role in the virulence of Gram‐positive and Gram‐negative bacteria. In Porphyromonas gingivalis, six serotypes have been described based on capsular antigenicity and its pathogenicity has been correlated both in vitro and in animal models. This study aimed to investigate the differential response of human dendritic cells (DCs) when stimulated with different P. gingivalis capsular serotypes.
Materials and Methods: Using different multiplicity of infection (MOI) of the encapsulated strains K1–K6 and the non‐encapsulated K− strain of P. gingivalis, the mRNA expression levels for interleukin (IL)‐1β, IL‐2, IL‐5, IL‐6, IL‐10, IL‐12, IL‐13, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α, and TNF‐β in stimulated DCs were quantified by real‐time reverse transcription‐polymerase chain reaction.
Results: All P. gingivalis capsular serotypes induced a T‐helper type 1 (Th1) pattern of cytokine expression. K1‐ and K2‐stimulated DCs expressed higher levels of IL‐1β, IL‐6, IL‐12p35, IL‐12p40, and IFN‐γ and at lower MOI than DCs stimulated with the other strains.
Conclusions: These results demonstrate a differential potential of P. gingivalis capsular serotypes to induce DC responses and a higher capacity of strains K1 W83 and K2 HG184 than other K serotypes to trigger cytokine expression. |
| doi_str_mv | 10.1111/j.1600-051X.2009.01462.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734046497</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20829017</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5842-eae95e4ae0ece1a5bb2bfb3e84b587bbe12387fefdff4db7980bc24bfd95a833</originalsourceid><addsrcrecordid>eNqNkUtv1DAURi0EosPAX0DeAKsEP_LyBolOH4Cq0kUlZmfZyXXracZO7QQmG347CTMMO4Q3tnTP_ezrgxCmJKXTer9JaUFIQnK6ThkhIiU0K1i6e4IWx8JTtCCc8KQQpThBL2LcEEJLzvlzdEJFUTFasgX6eWaNgQCut6rF9dj7B-sAw64LEKP1DusR3w9b5XADrgm2tzWuoW0jtg5PTOddBNx73PwJwjc-dPdj8FvvVMR31t3Z76q1Edeqi0OrAo4QfD92EF-iZ0a1EV4d9iW6vTi_XX1Krr5efl59vErqvMpYAgpEDpkCAjVQlWvNtNEcqkznVak1UMar0oBpjMkaXYqK6Jpl2jQiVxXnS_RuH9sF_zhA7OXWxnkK5cAPUZY8I1mRiXIi3_6TZKRiYv7HJar2YB18jAGM7ILdqjBKSuQsSW7k7ELOLuQsSf6WJHdT6-vDHYPeQvO38WBlAt4cABVr1ZqgXG3jkWNUMJELMXEf9twP28L43w-QX1Y35_NxCkj2ATb2sDsGqPAgi5KXufx2fSnZxRk5XZ9eyzX_BXZhwe4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20829017</pqid></control><display><type>article</type><title>Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Vernal, Rolando ; León, Rubén ; Silva, Augusto ; Van Winkelhoff, Arie J. ; Garcia-Sanz, Jose A. ; Sanz, Mariano</creator><creatorcontrib>Vernal, Rolando ; León, Rubén ; Silva, Augusto ; Van Winkelhoff, Arie J. ; Garcia-Sanz, Jose A. ; Sanz, Mariano</creatorcontrib><description>Aim: Capsular polysaccharides play an important role in the virulence of Gram‐positive and Gram‐negative bacteria. In Porphyromonas gingivalis, six serotypes have been described based on capsular antigenicity and its pathogenicity has been correlated both in vitro and in animal models. This study aimed to investigate the differential response of human dendritic cells (DCs) when stimulated with different P. gingivalis capsular serotypes.
Materials and Methods: Using different multiplicity of infection (MOI) of the encapsulated strains K1–K6 and the non‐encapsulated K− strain of P. gingivalis, the mRNA expression levels for interleukin (IL)‐1β, IL‐2, IL‐5, IL‐6, IL‐10, IL‐12, IL‐13, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α, and TNF‐β in stimulated DCs were quantified by real‐time reverse transcription‐polymerase chain reaction.
Results: All P. gingivalis capsular serotypes induced a T‐helper type 1 (Th1) pattern of cytokine expression. K1‐ and K2‐stimulated DCs expressed higher levels of IL‐1β, IL‐6, IL‐12p35, IL‐12p40, and IFN‐γ and at lower MOI than DCs stimulated with the other strains.
Conclusions: These results demonstrate a differential potential of P. gingivalis capsular serotypes to induce DC responses and a higher capacity of strains K1 W83 and K2 HG184 than other K serotypes to trigger cytokine expression.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/j.1600-051X.2009.01462.x</identifier><identifier>PMID: 19682172</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animal models ; Antigenicity ; Antigens, Bacterial - immunology ; Bacterial Capsules - classification ; Bacterial Capsules - immunology ; Biological and medical sciences ; Capsular polysaccharides ; capsular serotypes ; Cells, Cultured ; Cytokines ; Cytokines - analysis ; Cytokines - immunology ; Dendritic cells ; Dendritic Cells - immunology ; Dentistry ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; g-Interferon ; Gene expression ; Gram-negative bacteria ; Helper cells ; Humans ; Interferon-gamma - analysis ; Interleukin 1 ; Interleukin 10 ; Interleukin 12 ; Interleukin 13 ; Interleukin 2 ; Interleukin 5 ; Interleukin 6 ; Interleukin-10 - analysis ; Interleukin-12 - analysis ; Interleukin-12 Subunit p35 - analysis ; Interleukin-12 Subunit p40 - analysis ; Interleukin-13 - analysis ; Interleukin-1beta - analysis ; Interleukin-2 - analysis ; Interleukin-5 - analysis ; Interleukin-6 - analysis ; Lymphocytes T ; Lymphotoxin-alpha - analysis ; Medical sciences ; Multiplicity of infection ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Pathogenicity ; Polysaccharides, Bacterial - immunology ; Porphyromonas gingivalis ; Porphyromonas gingivalis - classification ; Porphyromonas gingivalis - immunology ; Porphyromonas gingivalis - pathogenicity ; Serotypes ; Serotyping ; Th1 Cells - immunology ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - analysis ; Virulence</subject><ispartof>Journal of clinical periodontology, 2009-10, Vol.36 (10), p.823-829</ispartof><rights>2009 John Wiley & Sons A/S</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5842-eae95e4ae0ece1a5bb2bfb3e84b587bbe12387fefdff4db7980bc24bfd95a833</citedby><cites>FETCH-LOGICAL-c5842-eae95e4ae0ece1a5bb2bfb3e84b587bbe12387fefdff4db7980bc24bfd95a833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21929599$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19682172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vernal, Rolando</creatorcontrib><creatorcontrib>León, Rubén</creatorcontrib><creatorcontrib>Silva, Augusto</creatorcontrib><creatorcontrib>Van Winkelhoff, Arie J.</creatorcontrib><creatorcontrib>Garcia-Sanz, Jose A.</creatorcontrib><creatorcontrib>Sanz, Mariano</creatorcontrib><title>Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim: Capsular polysaccharides play an important role in the virulence of Gram‐positive and Gram‐negative bacteria. In Porphyromonas gingivalis, six serotypes have been described based on capsular antigenicity and its pathogenicity has been correlated both in vitro and in animal models. This study aimed to investigate the differential response of human dendritic cells (DCs) when stimulated with different P. gingivalis capsular serotypes.
Materials and Methods: Using different multiplicity of infection (MOI) of the encapsulated strains K1–K6 and the non‐encapsulated K− strain of P. gingivalis, the mRNA expression levels for interleukin (IL)‐1β, IL‐2, IL‐5, IL‐6, IL‐10, IL‐12, IL‐13, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α, and TNF‐β in stimulated DCs were quantified by real‐time reverse transcription‐polymerase chain reaction.
Results: All P. gingivalis capsular serotypes induced a T‐helper type 1 (Th1) pattern of cytokine expression. K1‐ and K2‐stimulated DCs expressed higher levels of IL‐1β, IL‐6, IL‐12p35, IL‐12p40, and IFN‐γ and at lower MOI than DCs stimulated with the other strains.
Conclusions: These results demonstrate a differential potential of P. gingivalis capsular serotypes to induce DC responses and a higher capacity of strains K1 W83 and K2 HG184 than other K serotypes to trigger cytokine expression.</description><subject>Animal models</subject><subject>Antigenicity</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial Capsules - classification</subject><subject>Bacterial Capsules - immunology</subject><subject>Biological and medical sciences</subject><subject>Capsular polysaccharides</subject><subject>capsular serotypes</subject><subject>Cells, Cultured</subject><subject>Cytokines</subject><subject>Cytokines - analysis</subject><subject>Cytokines - immunology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Dentistry</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>g-Interferon</subject><subject>Gene expression</subject><subject>Gram-negative bacteria</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Interferon-gamma - analysis</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin 12</subject><subject>Interleukin 13</subject><subject>Interleukin 2</subject><subject>Interleukin 5</subject><subject>Interleukin 6</subject><subject>Interleukin-10 - analysis</subject><subject>Interleukin-12 - analysis</subject><subject>Interleukin-12 Subunit p35 - analysis</subject><subject>Interleukin-12 Subunit p40 - analysis</subject><subject>Interleukin-13 - analysis</subject><subject>Interleukin-1beta - analysis</subject><subject>Interleukin-2 - analysis</subject><subject>Interleukin-5 - analysis</subject><subject>Interleukin-6 - analysis</subject><subject>Lymphocytes T</subject><subject>Lymphotoxin-alpha - analysis</subject><subject>Medical sciences</subject><subject>Multiplicity of infection</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pathogenicity</subject><subject>Polysaccharides, Bacterial - immunology</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - classification</subject><subject>Porphyromonas gingivalis - immunology</subject><subject>Porphyromonas gingivalis - pathogenicity</subject><subject>Serotypes</subject><subject>Serotyping</subject><subject>Th1 Cells - immunology</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Virulence</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAURi0EosPAX0DeAKsEP_LyBolOH4Cq0kUlZmfZyXXracZO7QQmG347CTMMO4Q3tnTP_ezrgxCmJKXTer9JaUFIQnK6ThkhIiU0K1i6e4IWx8JTtCCc8KQQpThBL2LcEEJLzvlzdEJFUTFasgX6eWaNgQCut6rF9dj7B-sAw64LEKP1DusR3w9b5XADrgm2tzWuoW0jtg5PTOddBNx73PwJwjc-dPdj8FvvVMR31t3Z76q1Edeqi0OrAo4QfD92EF-iZ0a1EV4d9iW6vTi_XX1Krr5efl59vErqvMpYAgpEDpkCAjVQlWvNtNEcqkznVak1UMar0oBpjMkaXYqK6Jpl2jQiVxXnS_RuH9sF_zhA7OXWxnkK5cAPUZY8I1mRiXIi3_6TZKRiYv7HJar2YB18jAGM7ILdqjBKSuQsSW7k7ELOLuQsSf6WJHdT6-vDHYPeQvO38WBlAt4cABVr1ZqgXG3jkWNUMJELMXEf9twP28L43w-QX1Y35_NxCkj2ATb2sDsGqPAgi5KXufx2fSnZxRk5XZ9eyzX_BXZhwe4</recordid><startdate>200910</startdate><enddate>200910</enddate><creator>Vernal, Rolando</creator><creator>León, Rubén</creator><creator>Silva, Augusto</creator><creator>Van Winkelhoff, Arie J.</creator><creator>Garcia-Sanz, Jose A.</creator><creator>Sanz, Mariano</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200910</creationdate><title>Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes</title><author>Vernal, Rolando ; León, Rubén ; Silva, Augusto ; Van Winkelhoff, Arie J. ; Garcia-Sanz, Jose A. ; Sanz, Mariano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5842-eae95e4ae0ece1a5bb2bfb3e84b587bbe12387fefdff4db7980bc24bfd95a833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animal models</topic><topic>Antigenicity</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacterial Capsules - classification</topic><topic>Bacterial Capsules - immunology</topic><topic>Biological and medical sciences</topic><topic>Capsular polysaccharides</topic><topic>capsular serotypes</topic><topic>Cells, Cultured</topic><topic>Cytokines</topic><topic>Cytokines - analysis</topic><topic>Cytokines - immunology</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Dentistry</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>g-Interferon</topic><topic>Gene expression</topic><topic>Gram-negative bacteria</topic><topic>Helper cells</topic><topic>Humans</topic><topic>Interferon-gamma - analysis</topic><topic>Interleukin 1</topic><topic>Interleukin 10</topic><topic>Interleukin 12</topic><topic>Interleukin 13</topic><topic>Interleukin 2</topic><topic>Interleukin 5</topic><topic>Interleukin 6</topic><topic>Interleukin-10 - analysis</topic><topic>Interleukin-12 - analysis</topic><topic>Interleukin-12 Subunit p35 - analysis</topic><topic>Interleukin-12 Subunit p40 - analysis</topic><topic>Interleukin-13 - analysis</topic><topic>Interleukin-1beta - analysis</topic><topic>Interleukin-2 - analysis</topic><topic>Interleukin-5 - analysis</topic><topic>Interleukin-6 - analysis</topic><topic>Lymphocytes T</topic><topic>Lymphotoxin-alpha - analysis</topic><topic>Medical sciences</topic><topic>Multiplicity of infection</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pathogenicity</topic><topic>Polysaccharides, Bacterial - immunology</topic><topic>Porphyromonas gingivalis</topic><topic>Porphyromonas gingivalis - classification</topic><topic>Porphyromonas gingivalis - immunology</topic><topic>Porphyromonas gingivalis - pathogenicity</topic><topic>Serotypes</topic><topic>Serotyping</topic><topic>Th1 Cells - immunology</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vernal, Rolando</creatorcontrib><creatorcontrib>León, Rubén</creatorcontrib><creatorcontrib>Silva, Augusto</creatorcontrib><creatorcontrib>Van Winkelhoff, Arie J.</creatorcontrib><creatorcontrib>Garcia-Sanz, Jose A.</creatorcontrib><creatorcontrib>Sanz, Mariano</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vernal, Rolando</au><au>León, Rubén</au><au>Silva, Augusto</au><au>Van Winkelhoff, Arie J.</au><au>Garcia-Sanz, Jose A.</au><au>Sanz, Mariano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2009-10</date><risdate>2009</risdate><volume>36</volume><issue>10</issue><spage>823</spage><epage>829</epage><pages>823-829</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim: Capsular polysaccharides play an important role in the virulence of Gram‐positive and Gram‐negative bacteria. In Porphyromonas gingivalis, six serotypes have been described based on capsular antigenicity and its pathogenicity has been correlated both in vitro and in animal models. This study aimed to investigate the differential response of human dendritic cells (DCs) when stimulated with different P. gingivalis capsular serotypes.
Materials and Methods: Using different multiplicity of infection (MOI) of the encapsulated strains K1–K6 and the non‐encapsulated K− strain of P. gingivalis, the mRNA expression levels for interleukin (IL)‐1β, IL‐2, IL‐5, IL‐6, IL‐10, IL‐12, IL‐13, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α, and TNF‐β in stimulated DCs were quantified by real‐time reverse transcription‐polymerase chain reaction.
Results: All P. gingivalis capsular serotypes induced a T‐helper type 1 (Th1) pattern of cytokine expression. K1‐ and K2‐stimulated DCs expressed higher levels of IL‐1β, IL‐6, IL‐12p35, IL‐12p40, and IFN‐γ and at lower MOI than DCs stimulated with the other strains.
Conclusions: These results demonstrate a differential potential of P. gingivalis capsular serotypes to induce DC responses and a higher capacity of strains K1 W83 and K2 HG184 than other K serotypes to trigger cytokine expression.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19682172</pmid><doi>10.1111/j.1600-051X.2009.01462.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0303-6979 1600-051X |
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| subjects | Animal models Antigenicity Antigens, Bacterial - immunology Bacterial Capsules - classification Bacterial Capsules - immunology Biological and medical sciences Capsular polysaccharides capsular serotypes Cells, Cultured Cytokines Cytokines - analysis Cytokines - immunology Dendritic cells Dendritic Cells - immunology Dentistry Facial bones, jaws, teeth, parodontium: diseases, semeiology g-Interferon Gene expression Gram-negative bacteria Helper cells Humans Interferon-gamma - analysis Interleukin 1 Interleukin 10 Interleukin 12 Interleukin 13 Interleukin 2 Interleukin 5 Interleukin 6 Interleukin-10 - analysis Interleukin-12 - analysis Interleukin-12 Subunit p35 - analysis Interleukin-12 Subunit p40 - analysis Interleukin-13 - analysis Interleukin-1beta - analysis Interleukin-2 - analysis Interleukin-5 - analysis Interleukin-6 - analysis Lymphocytes T Lymphotoxin-alpha - analysis Medical sciences Multiplicity of infection Non tumoral diseases Otorhinolaryngology. Stomatology Pathogenicity Polysaccharides, Bacterial - immunology Porphyromonas gingivalis Porphyromonas gingivalis - classification Porphyromonas gingivalis - immunology Porphyromonas gingivalis - pathogenicity Serotypes Serotyping Th1 Cells - immunology Tumor necrosis factor Tumor Necrosis Factor-alpha - analysis Virulence |
| title | Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes |
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