Ocular adnexal lymphoma: no evidence for bacterial DNA associated with lymphoma pathogenesis

Summary Ocular Adnexal Lymphomas (OALs) are the most common tumors of the eye, the majority being extranodal mucosa‐associated lymphoid tissue (MALT) lymphomas. Association with Chlamydia psittaci was described in some geographic areas. OAL response to antibiotic therapy was reported in cases not ha...

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Bibliographic Details
Published in:British journal of haematology 2008-07, Vol.142 (2), p.246-249
Main Authors: Matthews, Julie M., Moreno, Lilliana I., Dennis, Jeremy, Byrne, Gerald E., Ruiz, Phillip, Dubovy, Sander R., Lossos, Izidore S.
Format: Article
Language:English
Subjects:
Bacteria
Biological and medical sciences
Chlamydia
Chlamydophila psittaci - genetics
Chlamydophila psittaci - isolation & purification
DNA, Bacterial - analysis
DNA, Bacterial - isolation & purification
Eye Neoplasms - complications
Eye Neoplasms - microbiology
Florida
Hematologic and hematopoietic diseases
Humans
Lymphoma, B-Cell, Marginal Zone - microbiology
MALT
Medical sciences
ocular adnexal lymphoma
Polymerase Chain Reaction - methods
Psittacosis - microbiology
RNA, Ribosomal, 16S - analysis
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Summary:Summary Ocular Adnexal Lymphomas (OALs) are the most common tumors of the eye, the majority being extranodal mucosa‐associated lymphoid tissue (MALT) lymphomas. Association with Chlamydia psittaci was described in some geographic areas. OAL response to antibiotic therapy was reported in cases not harboring Chlamydia psittaci DNA, suggesting that other bacterial infection might be implicated in the pathogenesis. We examined 49 MALT OALs for bacterial DNA using two distinct polymerase chain reaction techniques based on universal bacterial primers. No bacterial DNA that could be implicated in OAL pathogenesis was detected, suggesting that bacterial infection is not associated with OAL in South Florida.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2008.07112.x