Ras Pathway Modulator Melophlin A Targets Dynamins

Natural causes: A combination of organic synthesis, chemical proteomics, biophysics, and cell and molecular biology investigations reveals that the natural product melophlin A (purple) influences signal propagation through the Ras network by interfering with the function of dynamins (green) in endoc...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (39), p.7240-7245
Main Authors: Knoth, Tanja, Warburg, Karin, Katzka, Catherine, Rai, Amrita, Wolf, Alexander, Brockmeyer, Andreas, Janning, Petra, Reubold, Thomas F, Eschenburg, Susanne, Manstein, Dietmar J, Hübel, Katja, Kaiser, Markus, Waldmann, Herbert
Format: Article
Language:English
Subjects:
Alkanes - chemical synthesis
Alkanes - chemistry
biological activity
Biological Products - chemistry
Dynamins - metabolism
Genes, ras - genetics
Genes, ras - physiology
Humans
Mitogen-Activated Protein Kinases - chemistry
Mitogen-Activated Protein Kinases - metabolism
Molecular Structure
natural products
proteomics
Proteomics - standards
Pyrrolidinones - chemical synthesis
Pyrrolidinones - chemistry
Signal Transduction
solid‐phase synthesis
Structure-Activity Relationship
structure–activity relationships
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Summary:Natural causes: A combination of organic synthesis, chemical proteomics, biophysics, and cell and molecular biology investigations reveals that the natural product melophlin A (purple) influences signal propagation through the Ras network by interfering with the function of dynamins (green) in endocytosis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200902023