In vitro kinetics of hepatic albendazole sulfoxidation in channel catfish (Ictalurus punctatus), tilapia (Oreochromis sp.), rainbow trout (Oncorhynchus mykiss) and induction of EROD activity in ABZ-dosed channel catfish

Liver microsomes from market‐size (n = 6) rainbow trout, channel catfish and tilapia were used to investigate in vitro biotransformation kinetics of albendazole (ABZ). ABZ was transformed to a single metabolite, ABZ sulfoxide (ABZ‐SO). Catfish displayed the highest maximal velocity (Vmax = 264.0 ± 5...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2009-10, Vol.32 (5), p.429-435
Main Authors: GONZÁLEZ, J. F., SHAIKH, B., REIMSCHUESSEL, R., KANE, A. S.
Format: Article
Language:English
Subjects:
Albendazole - pharmacokinetics
Albendazole - pharmacology
Animals
Biotransformation
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP1A1 - biosynthesis
Cytochrome P-450 CYP1A1 - metabolism
Cytochrome P-450 CYP2B1 - metabolism
Enzyme Induction - drug effects
Glutathione Transferase - metabolism
Ictaluridae - metabolism
In Vitro Techniques
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Microsomes, Liver - metabolism
Oncorhynchus mykiss - metabolism
Tilapia - metabolism
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Summary:Liver microsomes from market‐size (n = 6) rainbow trout, channel catfish and tilapia were used to investigate in vitro biotransformation kinetics of albendazole (ABZ). ABZ was transformed to a single metabolite, ABZ sulfoxide (ABZ‐SO). Catfish displayed the highest maximal velocity (Vmax = 264.0 ± 58.6 pmols ABZ‐SO/min/mg protein) followed by tilapia (112.3 ± 8.2) and rainbow trout (73.3 ± 10.3). Vmax in catfish was significantly different (P 
ISSN:0140-7783
1365-2885
DOI:10.1111/j.1365-2885.2009.01056.x