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Novel Inhibitors of Procollagen C-Terminal Proteinase. Part 1: Diamino Acid Hydroxamates
The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the d-diaminopropionic acid derivatives were shown to be single digit...
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| Published in: | Bioorganic & medicinal chemistry letters 2003-07, Vol.13 (13), p.2101-2104 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c391t-caf6fe9610bf26694852bcc522b0857bf2c0065f8c79966b867eb6c9c5c16273 |
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| cites | cdi_FETCH-LOGICAL-c391t-caf6fe9610bf26694852bcc522b0857bf2c0065f8c79966b867eb6c9c5c16273 |
| container_end_page | 2104 |
| container_issue | 13 |
| container_start_page | 2101 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 13 |
| creator | Delaet, N.G.J. Robinson, L.A. Wilson, D.M. Sullivan, R.W. Bradley, E.K. Dankwardt, S.M. Martin, R.L. Van Wart, H.E. Walker, K.A.M. |
| description | The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the
d-diaminopropionic acid derivatives were shown to be single digit nanomolar PCP inhibitors.
The parallel synthesis and SAR studies of diamino acid hydroxamate inhibitors of procollagen C-terminal proteinase are reported. |
| doi_str_mv | 10.1016/S0960-894X(03)00404-9 |
| format | article |
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The parallel synthesis and SAR studies of diamino acid hydroxamate inhibitors of procollagen C-terminal proteinase are reported.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Bone Morphogenetic Protein 1</subject><subject>Bone Morphogenetic Proteins - antagonists & inhibitors</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrolases</subject><subject>Hydroxamic Acids - chemical synthesis</subject><subject>Hydroxamic Acids - pharmacology</subject><subject>Indicators and Reagents</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Metalloendopeptidases - antagonists & inhibitors</subject><subject>Miscellaneous</subject><subject>Pharmacology. 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| language | eng |
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| subjects | Analytical, structural and metabolic biochemistry Biological and medical sciences Bone Morphogenetic Protein 1 Bone Morphogenetic Proteins - antagonists & inhibitors Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Hydroxamic Acids - chemical synthesis Hydroxamic Acids - pharmacology Indicators and Reagents Kinetics Medical sciences Metalloendopeptidases - antagonists & inhibitors Miscellaneous Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Protease Inhibitors - pharmacology Structure-Activity Relationship |
| title | Novel Inhibitors of Procollagen C-Terminal Proteinase. Part 1: Diamino Acid Hydroxamates |
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