Effect of prostaglandin F2alpha on subclinical endometritis and fertility in dairy cows

The objectives were to determine the effects of PGF(2alpha) treatment on the prevalence of subclinical endometritis (SCE) and fertility of dairy cows. A total of 406 Holstein cows (167 primiparous and 239 multiparous) from 5 herds were used. Uterine lavage for diagnosis of SCE, PGF(2alpha) treatment...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dairy science 2009-10, Vol.92 (10), p.4906-4913
Main Authors: Galvão, K N, Frajblat, M, Brittin, S B, Butler, W R, Guard, C L, Gilbert, R O
Format: Article
Language:English
Subjects:
Animals
Cattle
Cattle Diseases - drug therapy
Cattle Diseases - prevention & control
Corpus Luteum - physiopathology
Dinoprost - administration & dosage
Endometritis - complications
Endometritis - diagnosis
Endometritis - prevention & control
Female
Fertility - drug effects
Infertility, Female - drug therapy
Infertility, Female - veterinary
Insemination, Artificial - veterinary
Lactation
Pregnancy
Progesterone - blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objectives were to determine the effects of PGF(2alpha) treatment on the prevalence of subclinical endometritis (SCE) and fertility of dairy cows. A total of 406 Holstein cows (167 primiparous and 239 multiparous) from 5 herds were used. Uterine lavage for diagnosis of SCE, PGF(2alpha) treatment, evaluation of body condition scores (BCS), and collection of blood samples for estrous cyclicity determination were performed at 21, 35, and 49 d in milk (DIM). Polymorphonuclear cells (PMN) were quantified and thresholds for diagnosing SCE were selected by receiver operating characteristics analysis. Cows classified as having SCE at 35 DIM (>or=6.5% PMN) and 49 DIM (>or=4.0% PMN) had increased time to pregnancy; however, cows classified as having SCE at 21 DIM (>or=8.5% PMN) did not. Median days to pregnancy were delayed by 30 (151 vs. 121 d) and 40 (169 vs. 129) d for cows classified as having SCE at 35 and 49 DIM, respectively. Treatment with PGF(2alpha) did not affect the prevalence of SCE either at 35 (37.9 vs. 38.4%) or at 49 DIM (34.0 vs. 40.4%). Treatment with PGF(2alpha) did not affect time to first insemination (AI; median 76 DIM for cows treated with PGF(2alpha); 79 DIM for control. Nonetheless, PGF(2alpha) treatment increased pregnancy to first AI in all the cows (35.5 vs. 24.1%) and hazard ratio (HR) of pregnancy in cows with BCS
ISSN:1525-3198
DOI:10.3168/jds.2008-1984