Design and biological evaluation of novel antioxidants containing N- t-Butyl- N-hydroxylaminophenyl moieties

In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N- t-butyl- N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects. Graphic

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2003-07, Vol.13 (14), p.2273-2275
Main Authors: Kim, Kyung-Mi, Kim, Kyung-Hwa, Kang, Tae-Cheon, Kim, Won-Yeon, Lee, Myung-ryul, Jung, Hyuk-Jun, Hwang, In Koo, Ko, Sung-Bo, Koh, Jae-Young, Won, Moo Ho, Oh, Eu-gene, Shin, Injae
Format: Article
Language:English
Subjects:
Animals
Antioxidants - chemical synthesis
Antioxidants - pharmacology
Azoles - pharmacology
Biological and medical sciences
Brain Ischemia - drug therapy
Brain Ischemia - pathology
Cell Death - drug effects
Cell Survival - drug effects
Drug Design
Electron Spin Resonance Spectroscopy
Free Radical Scavengers - chemical synthesis
Free Radical Scavengers - pharmacology
Gerbillinae
Hippocampus - pathology
Hydroxylamines - chemical synthesis
Hydroxylamines - pharmacology
Lipid Peroxidation - drug effects
Medical sciences
Neurons - drug effects
Neuropharmacology
Neuroprotective agent
Neuroprotective Agents - chemical synthesis
Neuroprotective Agents - pharmacology
Organoselenium Compounds - pharmacology
Oxidation-Reduction
Pharmacology. Drug treatments
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Description
Summary:In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N- t-butyl- N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(03)00444-X