Cardiovascular Risk in Patients with Nonfunctional Adrenal Incidentaloma: Myth or Reality?

• Published in: World journal of surgery 2009-10, Vol.33 (10), p.2099-2105
• Main Authors: Erbil, Yesim, Ozbey, Nese, Barbaros, Umut, Unalp, Haluk Recai, Salmaslıoglu, Artur, Özarmagan, Selçuk
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Adrenal Gland Neoplasms - complications; Adrenal Gland Neoplasms - epidemiology; Adrenal Incidentaloma; Adult; Atherosclerosis - epidemiology; Atherosclerosis - etiology; Biological and medical sciences; Brachial Artery; Cardiac Surgery; Cardiometabolic Risk Factor; Endothelium, Vascular; Female; General aspects; General Surgery; Humans; Incidence; Incidental Findings; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Middle Aged; Normetanephrine; Risk Factors; Surgery; Thoracic Surgery; Vascular Surgery; Waist Circumference
• ISSN: 0364-2313; 1432-2323
• DOI: 10.1007/s00268-009-0178-0

Background It is not clear whether nonfunctional adrenal incidentaloma (NFA) increases the risk of atherosclerosis and metabolic syndrome or whether this type of adrenal tumor has been found more frequently in patients with cardiometabolic risk factors. We aimed to determine the effects of NFA on cardiometabolic risk factors and endothelial function and to compare the patients with a 1:1 cardiometabolic risk factor matched control group. Methods Thirty-five patients with NFA were studied, and 35 body mass index-, age-, and sex-matched subjects were regarded as group 2 controls. Thirty-five cardiometabolic risk factors–matched subjects were then regarded as group 3 controls. Results Patients with NFA had significantly lower flow-mediated dilation (FMD)—a parameter for endothelial function—measurements compared with groups 2 and 3 (7.1 ± 2.9% vs. 12.9 ± 3.8% and 13.5 ± 4.5%; P