Primary amoebic meningoencephalitis: two new cases from Pakistan

Naegleria fowleri causes a fatal infection of the central nervous system. Only one case of N. fowleri meningoencephalitis has previously been reported from Pakistan. We describe two cases of primary amoebic meningoencephalitis. A 24-year-old man presented with a two-day history of high grade fever,...

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Bibliographic Details
Published in:Tropical doctor 2009-10, Vol.39 (4), p.242-243
Main Authors: Saleem, Taimur, Rabbani, Madiha, Jamil, Bushra
Format: Article
Language:English
Subjects:
Adult
Amebiasis - diagnosis
Amebiasis - drug therapy
Amebicides - therapeutic use
Amibiasis
Animals
Biological and medical sciences
Fatal Outcome
General aspects
Human protozoal diseases
Humans
Infectious diseases
Male
Medical sciences
Meningoencephalitis - diagnosis
Meningoencephalitis - drug therapy
Meningoencephalitis - parasitology
Naegleria fowleri - isolation & purification
Pakistan
Parasitic diseases
Protozoal diseases
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Summary:Naegleria fowleri causes a fatal infection of the central nervous system. Only one case of N. fowleri meningoencephalitis has previously been reported from Pakistan. We describe two cases of primary amoebic meningoencephalitis. A 24-year-old man presented with a two-day history of high grade fever, headaches and vomiting. He was put on intrathecal amphotericin B, fluconazole and rifampicin when motile trophozoites were identified on a wet mount of cerebrospinal fluid. The patient did not improve and died on the sixth day of admission. The second case was a 30-year-old man who presented with a three-day history of high grade fever, vomiting and agitation. His clinical course was marked by a rapid deterioration. He received intrathecal amphotericin B, fluconazole and broad spectrum antibiotics when motile trophozoites on wet mount were observed. Again, the patient's condition did not improve and he died on the eighth day of admission.
ISSN:0049-4755
1758-1133
DOI:10.1258/td.2009.090032