Renal Transplantation and Idiopathic Thrombocytopenic Purpura: Two Case Reports

Abstract Kidney transplantation has rarely been performed in patients with immune thrombocytopenic purpura (ITP). We present two cases of kidney recipients from unrelated donors in women who had prior chronic refractory ITP. Their immunosuppression included induction therapy with antithymocyte globu...

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Bibliographic Details
Published in:Transplantation proceedings 2009-09, Vol.41 (7), p.2923-2923
Main Author: Einollahi, B
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hematologic and hematopoietic diseases
Humans
Immunosuppressive Agents - therapeutic use
Kidney Failure, Chronic - surgery
Kidney Transplantation - immunology
Kidney Transplantation - physiology
Medical sciences
Platelet Count
Platelet diseases and coagulopathies
Purpura, Thrombocytopenic, Idiopathic - complications
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Abstract Kidney transplantation has rarely been performed in patients with immune thrombocytopenic purpura (ITP). We present two cases of kidney recipients from unrelated donors in women who had prior chronic refractory ITP. Their immunosuppression included induction therapy with antithymocyte globulin (ATG) and maintenance treatment with cyclosporine and prednisone. Kidney transplantations were safely performed without any complication. The platelet count of our patients increased gradually after the surgery, and maintenance with cyclosporine, mycophenolate mofetil, and prednisolone allowed graft function and satisfactory hemostasis. During the 3- and 8-year follow-up periods in our recipients, graft function was well maintained. We speculated that immunosuppressive agents, especially cyclosporine, may result in safe platelet counts and resolve thrombocytopenia in cases with refractory ITP prior to transplantation.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2009.07.010