efficiency of purifying selection in Mammals vs. Drosophila for metabolic genes

The nearly neutral theory of molecular evolution states that the efficiency of natural selection depends on the effective population size. By using a wide range of multispecies data on nucleotide polymorphism, we have tried to ascertain whether there are any differences in the level of selective con...

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Bibliographic Details
Published in:Journal of evolutionary biology 2009-10, Vol.22 (10), p.2118-2124
Main Authors: PETIT, N, BARBADILLA, A
Format: Article
Language:English
Subjects:
Animals
Comparative studies
Drosophila
Drosophila - genetics
Drosophila - metabolism
effective population size
evolution
Evolutionary biology
genetic drift
Genetics
Mammals - genetics
Mammals - metabolism
Metabolism - genetics
Molecular biology
nearly neutral theory
polymorphism
Polymorphism, Genetic
Recombination, Genetic
Selection, Genetic
Theory
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Summary:The nearly neutral theory of molecular evolution states that the efficiency of natural selection depends on the effective population size. By using a wide range of multispecies data on nucleotide polymorphism, we have tried to ascertain whether there are any differences in the level of selective constraints of metabolic process genes between Mammals and Drosophila species. The results are consistent with a higher selective constraint in Drosophila than in Mammals, according to the expected under the nearly neutral model: purifying selection seems to be more efficient in species with a larger effective population size.
ISSN:1010-061X
1420-9101
DOI:10.1111/j.1420-9101.2009.01814.x