Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch

An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neo...

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Bibliographic Details
Published in:Reproduction in domestic animals 2009-10, Vol.44 (5), p.855-858
Main Authors: Park, JK, Goo, MJ, Hong, IH, Ki, MR, Han, JY, Jeong, KS
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - analysis
Animals
Biological and medical sciences
Case studies
Dog Diseases - diagnosis
Dog Diseases - pathology
Dog Diseases - surgery
Dogs
Dysgerminoma - diagnosis
Dysgerminoma - surgery
Dysgerminoma - veterinary
Female
Females
Fundamental and applied biological sciences. Psychology
Immunohistochemistry - veterinary
Mammalian reproduction. General aspects
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - surgery
Ovarian Neoplasms - veterinary
Reproductive system
Vertebrates: reproduction
Veterinary medicine
Vimentin - analysis
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Summary:An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-α and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma.
ISSN:0936-6768
1439-0531
DOI:10.1111/j.1439-0531.2008.01135.x